ArticleBlood2023
BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.
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Article in Blood, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- Histiocytosis development and clinical variation through the lens of genomics.The Journal of pathology · 2026Review
- Blastic plasmacytoid dendritic cell neoplasm following Langerhans cell histiocytosis.JAAD case reports · 2026Article
- Common ancestral origin of indeterminate dendritic cell tumor and chronic myelomonocytic leukemia in clonal hematopoiesis.Haematologica · 2026Article
- An Adult Case of Chest Wall Langerhans Cell Histiocytosis Mimicking Malignancy and Responding to Targeted Therapy.Cureus · 2026Article
- Histiocyte Society blueprint for Langerhans cell histiocytosis research: from cell-of-origin to a more comprehensive cure.Haematologica · 2025Review
- NTRK1-rearranged histiocytosis: clinicopathologic and molecular features.Blood advances · 2025Article
- Eruptive widespread crateriform papulonodules and back pain: An interesting case of Langerhans cell histiocytosis?JAAD case reports · 2025Article
- Risk of Second Cancer in Erdheim-Chester Disease.JAMA oncology · 2025Article
- IDCH: is it now determined?Blood advances · 2025Article
- Recurrent ETV3::NCOA2 fusions and MAPK pathway mutations in indeterminate dendritic cell histiocytosis.Blood advances · 2025Article
- Pulmonary Langerhans cell histiocytosis: A case series and literature review.Journal of clinical imaging science · 2025Article
- Co-occurrence of Erdheim-Chester disease and clonally evolving acute myeloid leukemia with FLT3-ITD and PTPN11 mutations.Annals of hematology · 2024Article
- Langerhans cell histiocytosis of the suprasellar region: diagnosis based on thyroid cytology.European thyroid journal · 2024Article
- [Progress of BRAF Gene Alteration in Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Review
- Comprehensive considerations for dermatologists: the application of FDG-PET in evaluating cutaneous lesions in pediatric Langerhans cell histiocytosis.Frontiers in medicine · 2024Review
- Long-term outcomes among adults with Langerhans cell histiocytosis.Blood advances · 2023Article
- Solitary gastric langerhans cell histiocytosis treated by endoscopic submucosal dissection: A case report and literature review.Science progressReview
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Authors and funding
39 authors at 10 institutions in 2 countries.
Aldo A Acosta-MedinaDepartment of Internal Medicine, Mayo Clinic, Rochester, MN.ORCID 0000-0001-9414-9153
Paul G KempsDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-9793-7032
Timo C E ZondagSection Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0003-2979-7044
Jithma P AbeykoonDivision of Hematology, Mayo Clinic, Rochester, MN.ORCID 0000-0003-3939-6252
Jelske Forma-BorstDepartment of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Eline C SteenwijkDepartment of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Elizabeth A M FeijenPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0001-8930-3160
Jop C TeepenPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0002-2647-2677
N Nora BennaniDivision of Hematology, Mayo Clinic, Rochester, MN.ORCID 0000-0001-8358-5953
Susan M SchramDivision of Hematology, Mayo Clinic, Rochester, MN.
Mithun V ShahDivision of Hematology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-5359-336X
Caroline Davidge-PittsDivision of Endocrinology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-9393-7745
Matthew J KosterDivision of Rheumatology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-2895-6755
Jay H RyuDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.ORCID 0000-0002-9576-2272
Robert VassalloDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
W Oliver TobinDepartment of Neurology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-8141-2394
Jason R YoungDepartment of Radiology, Mayo Clinic, Jacksonville, FL.ORCID 0000-0001-5351-8266
Surendra DasariDivision of Biomedical Statistics and Informatics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.ORCID 0000-0002-7972-3556
Karen RechDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.ORCID 0000-0001-6770-2339
Aishwarya RavindranDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-4503-440X
Arjen H G ClevenDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3672-4348
Robert M VerdijkDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-1437-214X
Carel J M van NoeselDepartment of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0001-7907-7390
Brian V BalgobindDepartment of Radiation Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0009-0009-0326-7345
Gerrit Joan BoumaDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0002-2772-7475
Peerooz SaeedDepartment of Ophthalmology, Orbital Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0003-1270-4534
Jos A M BramerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0003-4342-5933
Ruben A L de GroenDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2998-2066
Joost S P VermaatDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-1628-6256
Michiel A J van de SandePrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0002-9156-7656
Egbert F SmitDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-7329-6995
Anton W LangerakDepartment of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-2078-3220
Tom van WezelDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-5773-7730
Sanne H ToninoDepartment of Hematology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0002-3253-8759
Cor van den BosPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0002-6175-6077
Jan A M van LaarSection Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-8885-4929
Ronald S GoDivision of Hematology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-8284-3495
Gaurav GoyalDivision of Hematology, Mayo Clinic, Rochester, MN.ORCID 0000-0001-6148-5177
Astrid G S van HalterenDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-0563-4155
Leiden University Medical Center · NLMayo Clinic · USAmsterdam University Medical Centers · NLErasmus MC · NLMayo Clinic in Arizona · USPrincess Máxima Center · NLMayo Clinic in Florida · USEmma Kinderziekenhuis · NLUniversity Medical Center Groningen · NLUniversity of Alabama at Birmingham · US
Funding
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI LENTZ, STEVEN R · 2002 to 2021
$45.7MNCI NIH HHS P50 CA097274
Abstract
In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.
Indexed as
Histiocytosis, Langerhans-CellNeoplasms, Second PrimaryAdultHumansIncidenceMutationProto-Oncogene Proteins B-rafRetrospective StudiesBRAF protein, humanProto-Oncogene Proteins B-raf
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.