Evidence map›Paper›PMID 37595261›Full record

ArticleThe Journal of clinical endocrinology and metabolism2023

Executive Dysfunction in Klinefelter Syndrome: Associations With Brain Activation and Testicular Failure.

Lara C Foland-Ross, Elnaz Ghasemi, Vanessa Lozano Wun, Tandy Aye, Karen Kowal, Judith Ross, Allan L Reiss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Using Organoids to Model Sex Differences in the Human Brain.Biological psychiatry global open science · 2024
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lara C Foland-RossCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.ORCID 0000-0001-6358-4566
Elnaz GhasemiCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Vanessa Lozano WunDepartment of Psychology, University of Minnesota, Minneapolis, MN 55455, USA.
Tandy AyeDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 93405, USA.
Karen KowalDepartment of Pediatrics, Nemours Children's Hospital Delaware, Wilmington, DE 19803, USA.
Judith RossDepartment of Pediatrics, Nemours Children's Hospital Delaware, Wilmington, DE 19803, USA.
Allan L ReissCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Stanford University · USThomas Jefferson University · USUniversity of Minnesota · US

Funding

Brain and Behavior during Puberty in Klinefelter Syndrome.R01HD092847 · NICHD · STANFORD UNIVERSITY · PI REISS, ALLAN L, ROSS, JUDITH L · 2018 to 2023
$3.4M
NICHD NIH HHS R01 HD092847
6 · The paper itself

Abstract

contextExecutive dysfunction is a well-recognized component of the cognitive phenotype of Klinefelter syndrome (KS), yet the neural basis of KS-associated cognitive weaknesses, and their association with testicular failure is unknown.

objectiveWe investigated executive function, brain activation, and pubertal development in adolescents with and without KS.

methodsForty-three adolescents with KS (mean age 12.3 ± 2.3 years) and 41 typically developing boys (mean age 11.9 ± 1.8 years) underwent pubertal evaluation, behavioral assessment, and completed functional magnetic resonance imaging (fMRI) as they performed an executive function task, the go/no-go task. Group differences in activation were examined. Associations among activation, executive function, and pubertal development measures were tested in secondary analyses.

resultsBoys with KS exhibited reduced executive function, as well as lower activation in brain regions subserving executive function, including the inferior frontal gyrus, anterior insula, dorsal anterior cingulate cortex, and caudate nucleus. Secondary analyses indicated that the magnitude of activation differences in boys with KS was associated with severity of pubertal developmental delay, as indexed by lower testosterone (t(36) = 2.285; P = .028) and lower testes volume (t(36) = 2.238; P = .031). Greater parent-reported attention difficulties were additionally associated with lower testicular volume (t(36) = -2.028; P = .050).

conclusionThese findings indicate a neural basis for executive dysfunction in KS and suggest alterations in pubertal development may contribute to increased severity of this cognitive weakness. Future studies that examine whether these patterns change with testosterone replacement therapy are warranted.

Indexed as

Cognitive DysfunctionKlinefelter SyndromeAdolescentBrainChildExecutive FunctionHumansMaleTestosteroneTestosteronebrainexecutive functionfMRIinhibitionKlinefelter syndromesex chromosome aneuploidy

Identifiers

PMID37595261
PMCPMC10735320
OpenAlexW4385970789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.