Evidence map›Paper›PMID 37595138›Full record

SynthesisEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023

Catheter ablation of atrial fibrillation in patients with and without hypertrophic cardiomyopathy: systematic review and meta-analysis.

Fatima M Ezzeddine, Kolade M Agboola, Leslie C Hassett, Ammar M Killu, Freddy Del-Carpio Munoz, Christopher V DeSimone, Gurukripa N Kowlgi, Abhishek J Deshmukh, Konstantinos C Siontis

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Atrial electrophysiology in hypertrophic cardiomyopathy: current insights and knowledge gaps.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Atrioventricular node ablation for refractory atrial fibrillation in patients with hypertrophic cardiomyopathy: a case-control study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Prediction of new-onset atrial fibrillation in patients with hypertrophic cardiomyopathy using plasma proteomics profiling.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. An overview of the treatments for hypertrophic cardiomyopathy.Frontiers in cardiovascular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fatima M EzzeddineDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0002-6204-4557
Kolade M AgboolaDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0001-9253-738X
Leslie C HassettPlummer Library, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-1889-8387
Ammar M KilluDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0002-5525-1806
Freddy Del-Carpio MunozDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0001-9511-1245
Christopher V DeSimoneDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.
Gurukripa N KowlgiDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0002-0913-3497
Abhishek J DeshmukhDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0002-9560-1102
Konstantinos C SiontisDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 59905, USA.ORCID 0000-0002-6658-0971
Mayo Clinic · USBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is common in hypertrophic cardiomyopathy (HCM). There is limited data regarding the outcomes of AF catheter ablation in HCM patients. In this study, we aimed to synthesize all available evidence on the effectiveness of ablation of AF in patients with HCM compared to those without HCM. METHODS AND

resultsWe systematically reviewed bibliographic databases to identify studies published through February 2023. We included cohort studies with available quantitative information on rates of recurrent atrial arrhythmias, anti-arrhythmic drug (AAD) therapy, and repeat ablation procedures after initial AF ablation in patients with vs without HCM. Estimates were combined using random-effects meta-analysis models and reported as risk ratios (RR) and 95% confidence intervals (CI). Eight studies were included in quantitative synthesis (262 HCM and 642 non-HCM patients). During median follow-up 13-54 months across studies, AF recurrence rates ranged from 13.3% to 92.9% in HCM and 7.6% to 58.8% in non-HCM patients. The pooled RR for recurrent atrial arrhythmia after the first AF ablation in HCM patients compared to non-HCM controls was 1.498 (95% CI = 1.305-1.720; P < 0.001). During follow-up, HCM patients more often required AAD therapy (RR = 2.844; 95% CI = 1.713-4.856; P < 0.001) and repeat AF ablation (RR = 1.544; 95% CI = 1.070-2.228; P = 0.02). The pooled RR for recurrent atrial arrhythmias after the last AF ablation was higher in patients with HCM than those without HCM (RR = 1.607; 95% CI = 1.235-2.090; P < 0.001).

conclusionsCompared to non-HCM patients, those with HCM had higher rates of recurrent atrial arrhythmias, AAD use, and need for repeat AF ablation after initial ablation of AF.

Indexed as

Ablation TechniquesAtrial FibrillationCardiomyopathy, HypertrophicCardiovascular AgentsCatheter AblationHumansCardiovascular AgentsAtrial fibrillationCatheter ablationHypertrophic cardiomyopathyMeta-analysis

Identifiers

PMID37595138
PMCPMC10498139
OpenAlexW4385971014

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.