Evidence map›Paper›PMID 37594944›Full record

ArticlePloS one2023

Interaction effects between insomnia and depression on risk of out-of-hospital cardiac arrest: Multi-center study.

Eujene Jung, Hyun Ho Ryu, Sung Wan Kim, Jung Ho Lee, Kyoung Jun Song, Young Sun Ro, Kyoung Chul Cha, Sung Oh Hwang, Phase II Cardiac Arrest Pursuit Trial with Unique Registry and Epidemiologic Surveillance (CAPTURES-II investigators)

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Eujene JungDepartment of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea.
Hyun Ho RyuDepartment of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea.ORCID 0000-0002-0276-9994
Sung Wan KimDepartment of Psychiartry, Chonnam National University Medical School, Gwangju, Korea.
Jung Ho LeeDepartment of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea.
Kyoung Jun SongDepartment of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Young Sun RoDepartment of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.
Kyoung Chul ChaDepartment of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Sung Oh HwangDepartment of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Phase II Cardiac Arrest Pursuit Trial with Unique Registry and Epidemiologic Surveillance (CAPTURES-II investigators)
Chonnam National University · KRChonnam National University Hospital · KRYonsei University · KRSeoul National University · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsomnia and depression have been known to be risk factors of several diseases, including coronary heart disease. We hypothesized that insomnia affects the out-of-hospital cardiac arrest (OHCA) incidence, and these effects may vary depending on whether it is accompanied by depression. This study aimed to determine the association between insomnia and OHCA incidence and whether the effect of insomnia is influenced by depression.

methodsThis prospective multicenter case-control study was performed using Phase II Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiology Surveillance (CAPTURES-II) project database for OHCA cases and community-based controls in Korea. The main exposure was history of insomnia. We conducted conditional logistic regression analysis to estimate the effect of insomnia on the risk of OHCA incidence and performed interaction analysis between insomnia and depression. Finally, subgroup analysis was conducted in the patients with insomnia.

resultsInsomnia was not associated with increased OHCA risk (0.95 [0.64-1.40]). In the interaction analysis, insomnia interacted with depression on OHCA incidence in the young population. Insomnia was associated with significantly higher odds of OHCA incidence (3.65 [1.29-10.33]) in patients with depression than in those without depression (0.84 [0.59-1.17]). In the subgroup analysis, depression increased OHCA incidence only in patients who were not taking insomnia medication (3.66 [1.15-11.66]).

conclusionInsomnia with depression is a risk factor for OHCA in the young population. This trend was maintained only in the population not consuming insomnia medication. Early and active medical intervention for patients with insomnia may contribute to lowering the risk of OHCA.

Indexed as

Out-of-Hospital Cardiac ArrestCase-Control StudiesData Interpretation, StatisticalDepressionHumansProspective Studies

Identifiers

PMID37594944
PMCPMC10437782
OpenAlexW4385972111

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.