Evidence map›Paper›PMID 37594578›Full record

ArticlePediatric nephrology (Berlin, Germany)2024

Factors related to recurrence of proteinuria in childhood IgA nephropathy.

Yuko Shima, Hironobu Mukaiyama, Yu Tanaka, Wataru Shimabukuro, Kandai Nozu, Hiroshi Kaito, Ryojiro Tanaka, Mayumi Sako, Kazumoto Iijima, Daisuke Tokuhara and 2 more

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Yuko ShimaDepartment of Pediatrics, Wakayama Medical University, Kimiidera, Wakayama, 811-1, Japan. yukotk@wakayama-med.ac.jp.ORCID 0000-0003-3944-0110
Hironobu MukaiyamaDepartment of Pediatrics, Wakayama Medical University, Kimiidera, Wakayama, 811-1, Japan.
Yu TanakaDepartment of Pediatrics, Wakayama Medical University, Kimiidera, Wakayama, 811-1, Japan.
Wataru ShimabukuroDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, Nishihara-Cho, Okinawa, Japan.
Kandai NozuDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroshi KaitoPediatric Nephrology, Hyogo Children's Hospital, Kobe, Japan.
Ryojiro TanakaPediatric Nephrology, Hyogo Children's Hospital, Kobe, Japan.
Mayumi SakoDivision for Clinical Trials, Clinical Research Center, National Center for Child Health and Development, Tokyo, Japan.
Kazumoto IijimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Daisuke TokuharaDepartment of Pediatrics, Wakayama Medical University, Kimiidera, Wakayama, 811-1, Japan.
Norishige YoshikawaClinical Research Center, Takatsuki General Hospital, Takatsuki City, Osaka, Japan.
Koichi NakanishiDepartment of Child Health and Welfare (Pediatrics), Graduate School of Medicine, University of the Ryukyus, Nishihara-Cho, Okinawa, Japan.
Wakayama Medical University · JPKobe Children's Hospital · JPKobe University · JPUniversity of the Ryukyus · JPNational Center For Child Health and Development · JPTakatsuki General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProteinuria remission is the most significant predictive factor for kidney outcome in childhood IgA nephropathy (c-IgAN). Even if proteinuria remission can be obtained, some patients have recurrence of proteinuria in the long-term.

methodsThis is a retrospective analysis of 312 cases of proteinuria remission among 538 consecutive children with biopsy-proven IgAN from 1976 to 2013. To elucidate the incidence and factors related to recurrence of proteinuria in c-IgAN, we compare clinical and pathological findings between patients with and without recurrence of proteinuria.

resultsAmong 312 patients with remission of proteinuria, 91 (29.2%) had recurrence of proteinuria within the observation period (median 8 years). Using a multivariate Cox regression analysis, significant factors associated with recurrence of proteinuria were onset age (HR 1.13 [95%CI: 1.05-1.22], P = 0.002) and presence of hematuria after proteinuria remission (HR 2.11 [95%CI: 1.30-3.45], P = 0.003). The Kaplan-Meier analysis showed significant differences in CKD G3a-G5-free survival between the patients with no-recurrence of proteinuria, recurrence of proteinuria and non-proteinuria remission (P < 0.0001, log-rank test). Kidney survival was 100% in no-recurrence of proteinuria, 92.2% in recurrence of proteinuria, and 65.6% in non-proteinuria remission at 15 years. Cox analyses adjusted by proteinuria remission showed that recurrence of proteinuria (HR 03.10e

conclusionsApproximately 30% of patients with proteinuria remission had recurrence of proteinuria regardless of treatment. Both remission and recurrence of proteinuria are significant prognostic factors for kidney outcome. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Glomerulonephritis, IGAKidney Failure, ChronicChildHumansImmunoglobulin AProteinuriaRetrospective StudiesImmunoglobulin AChildrenHematuriaIgA nephropathyKidney outcomeRecurrence of proteinuria

Identifiers

PMID37594578
OpenAlexW4385968656

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.