ArticleInfection and immunity2023
Apolipoprotein E genotype affects innate susceptibility to
Jooyoung Cho, Katie L Alexander, Jessica L Ferrell, Lance A Johnson, Steven Estus, Sarah E F D'Orazio
Open access · greenAbstract read
In one paragraphArticle in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors at 1 institution in 1 country.
Jooyoung Cho *Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine , Lexington, Kentucky, USA.
Katie L Alexander *Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine , Lexington, Kentucky, USA.
Jessica L FerrellDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine , Lexington, Kentucky, USA.
Lance A JohnsonDepartment of Physiology, University of Kentucky College of Medicine , Lexington, Kentucky, USA.
Steven EstusDepartment of Physiology, University of Kentucky College of Medicine , Lexington, Kentucky, USA.
Sarah E F D'OrazioDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine , Lexington, Kentucky, USA.ORCID 0000-0003-0716-3518 University of Kentucky · US
Funding
University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Pamela Carmen Hull · 2013 to 2026
$38.3MAPOE Allele Switching as a Therapeutic Approach for Alzheimer's DiseaseR01AG080589 · NIA · UNIVERSITY OF KENTUCKY · PI Lance Allen Johnson · 2023 to 2026
$2.6MAPOE and the PPP: Glucose Metabolism and Oxidative Stress in Alzheimer's DiseaseR01AG060056 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2018 to 2022
$2.5MExamining the Effects of the Neuroprotective APOE2 Allele on Peripheral ImmunometabolismR01AG062550 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2019 to 2023
$2.2MThe surprising impact of APOE alleles on gut microbiome: does altering the microbiome reduce AD risk?R56AG057589 · NIA · UNIVERSITY OF KENTUCKY · PI ESTUS, STEVEN · 2018 to 2018
$610kRole of Intracellular Growth in Dissemination of Listeria from the GutR56AI132410 · NIAID · UNIVERSITY OF KENTUCKY · PI D'ORAZIO, SARAH E. F. · 2018 to 2018
$473kNCI NIH HHS P30 CA177558NIAID NIH HHS R56 AI132410NIA NIH HHS R01 AG060056NIA NIH HHS R01 AG062550NIA NIH HHS R01 AG080589NIA NIH HHS R56 AG057589
6 · The paper itselfAbstract
Apolipoprotein E (ApoE) is a lipid transport protein that is hypothesized to suppress proinflammatory cytokine production, particularly after stimulation with Toll-like receptor (TLR) ligands such as lipopolysaccharide (LPS). Studies using transgenic ApoE human replacement mice (APOE) expressing one of three different allelic variants suggest that there is a hierarchy in terms of responsiveness to proinflammatory stimuli such as APOE4/E4 > APOE3/E3 > APOE2/E2. In this study, we test the hypothesis that
Indexed as
Listeria monocytogenesListeriosisAnimalsApolipoprotein E2Apolipoprotein E3Apolipoprotein E4Apolipoproteins ECytokinesFemaleGenotypeHumansMaleMiceMice, Inbred C57BLMice, TransgenicApoe protein, mouseApolipoprotein E2Apolipoprotein E3Apolipoprotein E4Apolipoproteins ECytokinesfoodborne listeriosislipid transportmacrophagesTNFα
Identifiers
PMID37594272
PMCPMC10501219
OpenAlexW4385968708
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