Evidence map›Paper›PMID 37594236›Full record

ArticlePsychosomatic medicine2024

Parental Preconception Posttraumatic Stress Symptoms and Maternal Prenatal Inflammation Prospectively Predict Shorter Telomere Length in Children.

Gabrielle R Rinne, Judith E Carroll, Christine M Guardino, Madeleine U Shalowitz, Sharon Landesman Ramey, Christine Dunkel Schetter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Gabrielle R RinneFrom the Department of Psychology (Rinne, Dunkel Schetter), Cousins Center for Psychoneuroimmunology (Carroll), Department of Psychiatry and Biobehavioral Sciences (Carroll), Semel Institute for Neuroscience and Human Behavior (Carroll), David Geffen School of Medicine (Carroll), University of California, Los Angeles, Los Angeles, California; Department of Psychology (Guardino), Dickinson College, Carlisle, Pennsylvania; Department of Psychiatry and Behavioral Sciences (Shalowitz), Rush University Medical Center, Chicago, Illinois; and Fralin Biomedical Research Institute (Ramey), Virginia Polytechnic Institute and State University, Blacksburg, Virginia.ORCID 0000-0001-6433-3988
Judith E CarrollORCID 0000-0001-5516-0819
Christine M GuardinoORCID 0000-0002-1424-5311
Madeleine U ShalowitzORCID 0000-0001-8610-9434
Sharon Landesman RameyORCID 0000-0003-4630-7019
Christine Dunkel SchetterORCID 0000-0002-2671-0647
Barro Colorado Island · PAUniversity of California, Los Angeles · USDickinson College · USRush University Medical Center · US

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Community Child Health Network-Lake County, ILU01HD044226 · NICHD · NORTHSHORE UNIV HEALTHSYSTEM RES INST · PI SHALOWITZ, MADELEINE ULLMAN · 2003 to 2011
$3.9M
Community Response to Maternal/Child Health DisparitiesU01HD044245 · NICHD · CEDARS-SINAI MEDICAL CENTER · PI HOBEL, CALVIN J. · 2003 to 2011
$3.4M
Community Child Health Network: District of ColumbiaU01HD044253 · NICHD · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAMEY, SHARON LANDESMAN · 2007 to 2011
$3.3M
Community Child Health Network: BaltimoreU01HD044207 · NICHD · ST. MICHAEL'S HOSPITAL · PI VANCE, MAXINE · 2003 to 2012
$3.2M
Community Maternal &Child Health-Eastern North CarolinaU01HD044219 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THORP, JOHN M · 2003 to 2011
$3.1M
Preconception and Prenatal Stress: Pathways to Child Biology and BehaviorR01HD072021 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNKEL SCHETTER, CHRISTINE · 2013 to 2017
$3.0M
Data Coordination and Analyses Center for the Community and Child Health NetworkU01HD054791 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHINCHILLI, VERNON M · 2006 to 2011
$2.7M
Community Child Health Research in Washington, D.C.U01NR008929 · NINR · GEORGETOWN UNIVERSITY · PI RAMEY, SHARON LANDESMAN · 2003 to 2006
$630k
NICHD NIH HHS R01 HD072021NICHD NIH HHS U01 HD044207NICHD NIH HHS U01 HD044219NICHD NIH HHS U01 HD044226NICHD NIH HHS U01 HD044245NICHD NIH HHS U01 HD044253NICHD NIH HHS U01 HD054791NIMH NIH HHS T32 MH015750NINR NIH HHS U01 NR008929
6 · The paper itself

Abstract

objectiveParental trauma exposure and trauma-related distress can increase the risk of adverse health outcomes in offspring, but the pathways implicated in intergenerational transmission are not fully explicated. Accelerated biological aging may be one mechanism underlying less favorable health in trauma-exposed individuals and their offspring. This study examines the associations of preconception maternal and paternal posttraumatic stress disorder (PTSD) symptoms with child telomere length, and maternal prenatal C-reactive protein (CRP) as a biological mechanism.

methodsMothers ( n = 127) and a subset of the fathers ( n = 84) reported on PTSD symptoms before conception. Mothers provided blood spots in the second and third trimesters that were assayed for CRP. At age 4 years, children provided buccal cells for measurement of telomere length. Models adjusted for parental age, socioeconomic status, maternal prepregnancy body mass index, child biological sex, and child age.

resultsMothers' PTSD symptoms were significantly associated with shorter child telomere length ( β = -0.22, SE = 0.10, p = .023). Fathers' PTSD symptoms were also inversely associated with child telomere length ( β = -0.21, SE = 0.11), although nonsignificant ( p = .065). There was no significant indirect effect of mothers' PTSD symptoms on child telomere length through CRP in pregnancy, but higher second-trimester CRP was significantly associated with shorter child telomere length ( β = -0.35, SE = 0.18, p = .048).

conclusionsMaternal symptoms of PTSD before conception and second-trimester inflammation were associated with shorter telomere length in offspring in early childhood, independent of covariates. Findings indicate that intergenerational transmission of parental trauma may occur in part through accelerated biological aging processes and provide further evidence that prenatal proinflammatory processes program child telomere length.Open Science Framework Preregistration:https://osf.io/7c2d5/?view_only=cd0fb81f48db4b8f9c59fc8bb7b0ef97 .

Indexed as

C-Reactive ProteinInflammationPrenatal Exposure Delayed EffectsStress Disorders, Post-TraumaticTelomere ShorteningAdultChild, PreschoolFathersFemaleHumansMaleMothersPregnancyTelomereC-Reactive Protein

Identifiers

PMID37594236
PMCPMC10879462
OpenAlexW4385969179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.