Evidence map›Paper›PMID 37594048›Full record

ArticleBiomaterials science2023

Antimicrobial efficacy of a nitric oxide-releasing ampicillin conjugate catheter lock solution on clinically-isolated antibiotic-resistant bacteria.

Manjyot Kaur Chug, Lauren Griffin, Mark Garren, Emma Tharp, Grace H Nguyen, Hitesh Handa, Elizabeth J Brisbois

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Wearable nitric oxide-releasing antibacterial insert for preventing device-associated infections.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Manjyot Kaur ChugSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.
Lauren GriffinSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.ORCID http://orcid.org/0000-0002-4899-0184
Mark GarrenSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.ORCID http://orcid.org/0000-0001-5194-6558
Emma TharpSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.
Grace H NguyenSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.
Hitesh HandaSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.ORCID http://orcid.org/0000-0002-9369-7374
Elizabeth J BrisboisSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA. ejbrisbois@uga.edu.ORCID http://orcid.org/0000-0002-9283-5448
University of Georgia · US

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Bioinspired antifouling and thromboresistant polymers for blood-contacting interfacesR01HL151473 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL151473
6 · The paper itself

Abstract

Antibiotic lock therapy (ALT) is standard clinical practice for treating bacteremia linked with catheter-related bloodstream infections (CRBSIs). However, this strategy frequently fails against multi-drug-resistant bacteria in clinical settings. In this study, a novel approach to utilize a nitric oxide (NO) donor

Indexed as

Anti-Infective AgentsCatheter-Related InfectionsAmpicillinAnti-Bacterial AgentsBacteriaCathetersEscherichia coliHumansNitric OxideNitric Oxide DonorsAmpicillinAnti-Bacterial AgentsAnti-Infective AgentsNitric OxideNitric Oxide Donors

Identifiers

PMID37594048
PMCPMC10529818
OpenAlexW4383960148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.