ArticleInternational journal of psychiatry in medicine2024
Adverse childhood experiences and early initiation of substance use: A survival analysis.
Article in International journal of psychiatry in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.British journal of anaesthesia · 2025Pooled it
- Impact of childhood and parental smoking and substance use on nephrotic syndrome outcomes: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Before Birth, Beyond Childhood: Understanding the Influence of Prenatal Substance Exposure on Psychiatric Diagnoses.medRxiv : the preprint server for health sciences · 2026Article
- Development of Substance Use Problems: The Role of Adolescent Cannabis Age of Onset, Frequency of Use and Childhood Risk Factors.Research on child and adolescent psychopathology · 2026Article
- Beyond the brain circuit: a biopsychosocial integrative review of addiction neuroscience, epigenetic mechanisms, and multidisciplinary treatment.Frontiers in psychiatry · 2026Review
- Exploring the relationship between lifestyle factors and depressive symptoms in Korean adolescents amid the COVID-19 pandemic.BMC psychiatry · 2025Article
- Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.Psychological medicine · 2025Article
- Training School-Based Health Clinicians in New Mexico Regarding Adverse Childhood Experiences.Healthcare (Basel, Switzerland) · 2025Article
- Increased risk of non-fatal overdose associated with broad adverse childhood experiences among people who use drugs in New York City: a latent class analysis.The American journal of drug and alcohol abuse · 2025Article
- Scoping review of biological and psychosocial pathways that lead from childhood adversity to early-onset substance use.Frontiers in psychiatry · 2025Review
- Preventing Substance Use and Overdose Among Young Adults: The Role of Social Determinants of Health.Focus (American Psychiatric Publishing) · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveEarly adversity, such as adverse childhood experiences (ACEs), is a risk factor for the development of substance use disorder (SUD). ACEs are associated with earlier initiation of substance use. This study examined the relationship between ACEs and age of initiation of substance use using survival analysis. It is hypothesized that individuals with higher ACEs will have an earlier age of initiation.
methodParticipants were recruited from the University of Kentucky's Laboratory for Human Behavioral Pharmacology. Participants were 18 years or older, English speaking, and actively engaged in substance use. Participants were not in substance abuse treatment nor were they seeking treatment. ACE scores were calculated, and age of substance use initiation was recorded. A Cox proportional hazard model was used to examine the effect of ACE score on age of substance use initiation.
resultsA total of 107 participants completed the study. An average number of 2.3 ACEs (SD = 2.2) were endorsed with 24% of participants reporting 4 or more ACEs. Higher ACE scores were associated with cigarette smoking and non-medical prescription opioid use onset ( hazard ratio (HR) = 1.14, 95% CI=1.02-1.28,
conclusionsA significant association was found between higher ACE scores and earlier initiation of cigarette and non-medical prescription opioid use, consistent with prior research. Primary prevention of ACEs, screening for ACEs during childhood, and interventions for ACEs if detected, may help to reduce the risk of substance use/SUD in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.