Evidence map›Paper›PMID 37594023›Full record

ArticleInternational journal of experimental pathology2023

Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.

Sara Gomes Espírito Santo, Tereza Cristina Da Silva, Bruno Cogliati, Luís Fernando Barbisan, Guilherme Ribeiro Romualdo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of experimental pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sara Gomes Espírito SantoBotucatu Medical School, Experimental Research Unit (UNIPEX), Multimodel Drug Screening Platform - Laboratory of Chemically Induced and Experimental Carcinogenesis (MDSP-LCQE), São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.
Tereza Cristina Da SilvaSchool of Veterinary Medicine and Animal Science, Department of Pathology, University of São Paulo (USP), São Paulo, São Paulo State, Brazil.
Bruno CogliatiSchool of Veterinary Medicine and Animal Science, Department of Pathology, University of São Paulo (USP), São Paulo, São Paulo State, Brazil.
Luís Fernando BarbisanBotucatu Medical School, Experimental Research Unit (UNIPEX), Multimodel Drug Screening Platform - Laboratory of Chemically Induced and Experimental Carcinogenesis (MDSP-LCQE), São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.
Guilherme Ribeiro RomualdoBotucatu Medical School, Experimental Research Unit (UNIPEX), Multimodel Drug Screening Platform - Laboratory of Chemically Induced and Experimental Carcinogenesis (MDSP-LCQE), São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.ORCID 0000-0001-5320-8380
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo
6 · The paper itself

Abstract

Colorectal cancer, which is the third leading cause of cancer-related deaths worldwide, is a multistep disease, featuring preneoplastic aberrant crypt foci (ACF) as the early morphological manifestation. The roles of hemichannel-forming transmembrane Pannexin 1 (Panx1) protein have not been investigated in the context of colon carcinogenesis yet, although it has contrasting roles in other cancer types. Thus, this study was conducted to examine the effects of Panx1 knockout (Panx1

Indexed as

Aberrant Crypt FociColonic NeoplasmsPrecancerous Conditions1,2-DimethylhydrazineAnimalsCarcinogenesisColonConnexinsFemaleMiceNerve Tissue Proteins1,2-DimethylhydrazineConnexinsNerve Tissue ProteinsPanx1 protein, mouseaberrant crypt fociC57BL/6J mousecolon carcinogenesisdimethylhydrazine

Identifiers

PMID37594023
PMCPMC10652697
OpenAlexW4385969517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.