ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2024
Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Sleep disturbances and assisted reproduction outcomes in women undergoing IVF/ICSI: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Associations between sleep quality and assisted reproductive technology outcomes: a meta-analysis.Archives of gynecology and obstetrics · 2026Pooled it
- Sleep disturbances and female infertility: a systematic review.BMC women's health · 2024Pooled it
- Polycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Clinical characteristics and pregnancy outcomes in polycystic ovary syndrome complicated by obstructive sleep apnea: a correlative study.Frontiers in medicine · 2026Article
- Polysomnographic Analysis in Snoring Patients.Cureus · 2025Article
- Glucose and lipid metabolism in non-diabetic, non-obese patients with obstructive sleep apnea: sex differences.Frontiers in nutrition · 2025Article
- The Hourly Apnea-Hypopnea Duration Better Correlates with OSA-Related Nocturnal Hypoxemia and Excessive Daytime Sleepiness Rather Than AHI.Nature and science of sleep · 2025Article
- Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Obstructive Sleep Apnea: Analysis of NHANES Database and a Chinese Cohort.Nature and science of sleep · 2025Article
- Causal evidence of the relationship between polycystic ovary syndrome and obstructive sleep apnea in European and East Asian populations: a two-sample Mendelian randomization study.Journal of thoracic disease · 2024Article
- Good and uninterrupted sleep may be better for eggs.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesPolycystic ovary syndrome (PCOS) confers a high risk of obstructive sleep apnea (OSA). Here we investigated the effect of OSA on first in vitro fertilization (IVF) cycle metrics and outcomes in patients with PCOS.
methodsThis was a prospective cohort study of patients with PCOS undergoing their first IVF at a single tertiary center between October 1, 2021, and September 30, 2022. Patients were screened for OSA before IVF and grouped accordingly. Clinical and IVF cycle data were compared between groups.
resultsOSA was found in 37.2% of 156 patients with PCOS, with longer infertility duration (4.3 ± 2.5 vs. 3.4 ± 2.0 years) and lower levels of anti-Müllerian and luteinizing hormones than patients without OSA (6.44 ± 2.96 vs 8.69 ± 4.03 µg/L and 6.30 ± 5.02 vs 8.46 ± 6.09 U/L). Antral follicle count was lower in patients with OSA (28.9 ± 12.4 vs 33.2 ± 12.9). During ovarian stimulation, patients with OSA required significantly higher doses of gonadotropin (2080.8 ± 1008.7 vs 1682.8 ± 619.9 U) and had lower peak estradiol level (4473.5 ± 2693.0 vs 5455.7 ± 2955.1 pmol/L) and fewer retrieved oocytes, high-quality, and available embryos (17.8 ± 7.2 vs 21.9 ± 10.5, 4.5 ± 4.4 vs 6.2 ± 4.6, 5.2 ± 4.3 vs 7.4 ± 5.0). Eleven patients were excluded for having no embryos or missing transfer. Therefore, we analyzed the outcome of the first embryo transfer in 145 patients. The biochemical and clinical pregnancy rates were lower in patients with OSA than patients without OSA (51.9% vs 66.7% and 42.3% vs 60.2%). OSA was independently associated with clinical pregnancy rate after controlling for several confounders (
conclusionsOSA impairs female fertility in patients with polycystic ovary syndrome, suggesting an adverse effect on in vitro fertilization cycle stimulation characteristics and clinical outcomes. CITATION: Zhang Q, Wang Z, Ding J, et al. Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome.
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