Evidence map›Paper›PMID 37593638›Full record

ArticleHeliyon2023

Oral and gut microbial biomarkers of susceptibility to respiratory tract infection in adults: A feasibility study.

Claire A Woodall, Ashley Hammond, David Cleary, Andrew Preston, Peter Muir, Ben Pascoe, Samuel K Sheppard, Alastair D Hay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Cervicovaginal microbial features predictInfection and immunity · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Claire A WoodallSchool of Cellular and Molecular Medicine, Bristol Medical School, University of Bristol, Bristol, UK.
Ashley HammondCentre for Academic Primary Care, Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
David ClearyInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Andrew PrestonThe Milner Centre for Evolution and Department of Biology and Biochemistry, University of Bath, Bath, UK.
Peter MuirPublic Health England, Southwest Regional Laboratory, National Infection Service, Southmead Hospital, Bristol, UK.
Ben PascoeDepartment of Biology, University of Oxford, Oxford, UK.
Samuel K SheppardDepartment of Biology, University of Oxford, Oxford, UK.
Alastair D HayCentre for Academic Primary Care, Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
University of Bristol · GBUniversity of Oxford · GBSouthmead Hospital · GBUniversity of Bath · GBUniversity of Birmingham · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

We conducted a feasibility cohort study which aimed to recruit and retain adults from the community to collect saliva (oral) and stool (gut) samples at three time points, at the start of the study (baseline), during a respiratory tract infection (RTI) and post-RTI. Community RTIs place a huge burden on health care services, and a non-invasive microbial diagnostic tool to predict the most vulnerable to respiratory infection would be ideal. To this aim, we analysed oral-gut baseline samples comparing those who reported RTI symptoms to those who remained healthy throughout the study for microbial biomarkers of respiratory susceptibility. Amplicon sequence variants (ASV) were identified by 16S sequence profiling to reveal oral-gut microbes. Reverse transcriptase-polymerase chain reaction (RT-PCR) was applied to target common respiratory microbes. Two general practices were recruited, and the participant recruitment rate was 1.3%. A total of 40 adult participants were retained, of which 19 acquired an RTI whereas 21 remained healthy. In healthy baseline oral and gut samples, ASVs from participants with RTI symptoms compared to those who remained healthy were similar with a high relative abundance of

Indexed as

CommunityFeasibilityLongitudinalMicrobial biomarkersRespiratory tract infection

Identifiers

PMID37593638
PMCPMC10432180
OpenAlexW4385331844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.