ReviewRSC medicinal chemistry2023
Antibacterial activities of anthraquinones: structure-activity relationships and action mechanisms.
Review in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 93 citations in OpenAlex.
- Natural Product-Based Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Biotransformation-guided production of quinalizarin as an antibacterial agent against Acinetobacter baumannii.Applied microbiology and biotechnology · 2026Article
- Physcion isolated fromRSC advances · 2026Article
- New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-DerivedMarine drugs · 2026Article
- Synergistic application of Ascophyllum nodosum, Salix aegyptiaca, and gum arabic improves salt tolerance in Rubia tinctorum.Scientific reports · 2026Article
- All-in-one: a CGRP-encapsulated Rh-GelMA supramolecular dual-network hydrogel orchestrating immune-vascular coupling for diabetic wound healing.Journal of nanobiotechnology · 2026Article
- Novel Aloe-Emodin Derivatives as Potential Anticancer Agents: Synthesis, Characterization and Cytotoxic Activity.Molecules (Basel, Switzerland) · 2026Article
- A Computational Challenge of Guanine Quadruplex Involvement in Anticancer Antibiotics.International journal of molecular sciences · 2026Article
- Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus.Journal of nanobiotechnology · 2026Article
- Phytoextracts Used in the Treatment of Cryptosporidiosis and Giardiasis: Current State.Acta parasitologica · 2026Review
- Classification and Anti-Pathogens (Basel, Switzerland) · 2026Review
- Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers.Molecules (Basel, Switzerland) · 2026Review
- Article
- Antibacterial Activity of Zanthoxylum chalybeum, Aloe deserti, and Zanthoxylum usambarense.BioMed research international · 2026Article
- Integrated mechanistic and bioinformatics analysis of a traditional Chinese medicine compound MangHuang solution againstFrontiers in cellular and infection microbiology · 2026Article
- Environmental control of anthraquinone-flavonoid accumulation in wild plant species: biosynthetic pathways, ecological drivers, and adaptive significance.Frontiers in plant science · 2026Review
- In vitro antimicrobial potential and phytochemical analysis of root extracts of Rumex abyssinicus from southern Ethiopia.PloS one · 2026Article
- Optimizing Extraction Polarity for Multifunctional Bioactivities and Phenolic Composition inAntioxidants (Basel, Switzerland) · 2025Article
- A Comprehensive Review of Plant and Microbial Natural Compounds as Sources of PotentialBiotech (Basel (Switzerland)) · 2025Review
- Extraction and characterization of antibacterial marine polysaccharide K-Carrageenan from Kappaphycus alvarezii against multidrug-resistant wound associated bacteria.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the increasing prevalence of untreatable infections caused by antibiotic-resistant bacteria, the discovery of new drugs from natural products has become a hot research topic. The antibacterial activity of anthraquinones widely distributed in traditional Chinese medicine has attracted much attention. Herein, the structure and activity relationships (SARs) of anthraquinones as bacteriostatic agents are reviewed and elucidated. The substituents of anthraquinone and its derivatives are closely related to their antibacterial activities. The stronger the polarity of anthraquinone substituents is, the more potent the antibacterial effects appear. The presence of hydroxyl groups is not necessary for the antibacterial activity of hydroxyanthraquinone derivatives. Substitution of di-isopentenyl groups can improve the antibacterial activity of anthraquinone derivatives. The rigid plane structure of anthraquinone lowers its water solubility and results in the reduced activity. Meanwhile, the antibacterial mechanisms of anthraquinone and its analogs are explored, mainly including biofilm formation inhibition, destruction of the cell wall, endotoxin inhibition, inhibition of nucleic acid and protein synthesis, and blockage of energy metabolism and other substances.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.