Evidence map›Paper›PMID 37593570›Full record

ArticleRSC medicinal chemistry2023

The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models.

Luke R Odell, Nigel C Jones, Ngoc Chau, Mark J Robertson, Joseph I Ambrus, Fiona M Deane, Kelly A Young, Ainslie Whiting, Jing Xue, Kate Prichard and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Luke R OdellChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.ORCID https://orcid.org/0000-0001-7658-5103
Nigel C JonesDepartment of Neuroscience, Central Clinical School, Monash University Melbourne Victoria 3004 Australia.
Ngoc ChauCell Signaling Unit, Children's Medical Research Institute, The University of Sydney 214 Hawkesbury Road Westmead NSW 2145 Australia PRobinson@cmri.org.au +612 8865 2915.
Mark J RobertsonChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.
Joseph I AmbrusChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.
Fiona M DeaneChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.
Kelly A YoungChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.
Ainslie WhitingCell Signaling Unit, Children's Medical Research Institute, The University of Sydney 214 Hawkesbury Road Westmead NSW 2145 Australia PRobinson@cmri.org.au +612 8865 2915.
Jing XueCell Signaling Unit, Children's Medical Research Institute, The University of Sydney 214 Hawkesbury Road Westmead NSW 2145 Australia PRobinson@cmri.org.au +612 8865 2915.
Kate PrichardChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.
James A DanielCell Signaling Unit, Children's Medical Research Institute, The University of Sydney 214 Hawkesbury Road Westmead NSW 2145 Australia PRobinson@cmri.org.au +612 8865 2915.
Nick N GorganiCell Signaling Unit, Children's Medical Research Institute, The University of Sydney 214 Hawkesbury Road Westmead NSW 2145 Australia PRobinson@cmri.org.au +612 8865 2915.ORCID https://orcid.org/0000-0002-9929-8796
Terence J O'BrienDepartment of Neurology, The Alfred Hospital Commercial Road Melbourne Victoria 3004 Australia.
Phillip J RobinsonCell Signaling Unit, Children's Medical Research Institute, The University of Sydney 214 Hawkesbury Road Westmead NSW 2145 Australia PRobinson@cmri.org.au +612 8865 2915.
Adam McCluskeyChemistry, Centre for Chemical Biology, School of Environmental & Life Science, The University of Newcastle University Drive Callaghan NSW 2308 Australia Adam.McCluskey@newcastle.edu.au +612 4921 5472 +612 4921 6486.ORCID https://orcid.org/0000-0001-7125-863X
University of Newcastle Australia · AUThe University of Sydney · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We show that dansylcadaverine (1) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity (IC

Identifiers

PMID37593570
PMCPMC10429932
OpenAlexW4367154164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.