Evidence map›Paper›PMID 37593458›Full record

ArticleiScience2023

The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway.

Abdelhalim Azzi, Zhipeng Tao, Yang Sun, Hannah Erb, Carla Guarino, Xu Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Abdelhalim AzziCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Zhipeng TaoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Yang SunCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Hannah ErbCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Carla GuarinoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Xu WuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Harvard University · US

Funding

Targeting dynamic palmitoylation of TEAD transcription factorsR01CA238270 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAO, JUNHAO, WU, XU · 2019 to 2023
$2.7M
Targeting Hippo pathway in melanomaR01CA219814 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WU, XU, ZHENG, BIN · 2019 to 2023
$2.6M
NCI NIH HHS R01 CA219814NCI NIH HHS R01 CA238270
6 · The paper itself

Abstract

Circadian clock controls daily behavior and physiology. The activity of various signaling pathways affects clock gene expression. Here, we show that the core circadian clock gene

Indexed as

Gene networkMolecular interactionTranscriptomics

Identifiers

PMID37593458
PMCPMC10428131
OpenAlexW4384938887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.