Evidence map›Paper›PMID 37593108›Full record

ArticleFrontiers in chemistry2023

Novel albumin-binding multifunctional probe for synergistic enhancement of FL/MR dual-modal imaging and photothermal therapy.

Cheng Yu, Zhuyuan Ding, Huan Liu, Yulu Ren, Minping Zhang, Qiuling Liao, Tao Luo, Lujing Gao, Shiyi Lyu, Huiwen Tan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Cheng YuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhuyuan DingDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huan LiuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yulu RenDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Minping ZhangDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiuling LiaoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tao LuoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lujing GaoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shiyi LyuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huiwen TanDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Linan HuDepartment of Radiology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Zhu ChenDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Pengfei XuTranslational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China.
Enhua XiaoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Second Xiangya Hospital of Central South University · CNCentral South University · CNJining First People's Hospital · CNZhuzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fluorescence/magnetic resonance (FL/MR) dual-modal imaging could provide accurate tumor visualization to guide photothermal therapy (PTT) of cancer, which has attracted widespread attention from scientists. However, facile and effective strategies to synergistically enhance fluorescence intensity, MR contrast and photothermal efficacy have rarely been reported. This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIs can self-assemble with endogenous albumin to form drug-albumin complexes (GIAs), which exhibit excellent biocompatibility. Albumin can protect GIAs from the recognition and clearance by the mononuclear phagocytic system (MPS). High plasma concentration and long half-life allow GIAs to accumulate continuously in the tumor area through EPR effect and specific uptake of tumor. Because of the prolonged rotational correlation time (τR) of Gd chelates, GIAs exhibited superior MR contrast performance over GIs with more than 3 times enhancement of longitudinal relaxation efficiency (r

Indexed as

albumindrug deliveryfluorescence imagingMRIphotothermal therapy

Identifiers

PMID37593108
PMCPMC10427858
OpenAlexW4385457165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.