Evidence map›Paper›PMID 37593105›Full record

ArticleAdvances in cancer biology - metastasis2023

Benzophenone-3 exposure alters composition of tumor infiltrating immune cells and increases lung seeding of 4T1 breast cancer cells.

Stephanie M Morin, Kelly J Gregory, Brenda Medeiros, Tigist Terefe, Reyhane Hoshyar, Ahmed Alhusseiny, Shiuan Chen, Richard C Schwartz, D Joseph Jerry, Laura N Vandenberg and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in cancer biology - metastasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Benzophenone-3 alters expression of genes encoding vascularization and epithelial-mesenchymal transition functions during Trp53-null mammary tumorigenesis.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Stephanie M MorinPioneer Valley Life Sciences Institute, Springfield, MA, 01199, USA.
Kelly J GregoryPioneer Valley Life Sciences Institute, Springfield, MA, 01199, USA.
Brenda MedeirosDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, 01003, USA.
Tigist TerefePioneer Valley Life Sciences Institute, Springfield, MA, 01199, USA.
Reyhane HoshyarBreast Cancer and the Environment Research Program, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.
Ahmed AlhusseinyUniversity of Massachusetts Chan Medical School-Baystate, Department of Pathology, Springfield, MA, 01199, USA.
Shiuan ChenDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Richard C SchwartzBreast Cancer and the Environment Research Program, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.
D Joseph JerryDept of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, 01003, USA.
Laura N VandenbergDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, 01003, USA.
Sallie S SchneiderPioneer Valley Life Sciences Institute, Springfield, MA, 01199, USA.
Pioneer (United States) · USUniversity of Massachusetts Amherst · USMichigan State University · USCity of Hope · USUniversity of Massachusetts Chan Medical School · US

Funding

Menopausal transition - a window of susceptibility for the promotion of breast cancer by environmental exposuresU01ES026137 · NIEHS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, SHIUAN, NEUHAUSEN, SUSAN L. · 2015 to 2019
$4.8M
Coordinating Center for the Breast Cancer and the Environment Research ProgramU01ES026127 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI TRENTHAM-DIETZ, AMY · 2015 to 2019
$4.7M
Mammary carcinogenesis: pubertal and adult effects of high fat diet+oxybenzoneU01ES026119 · NIEHS · MICHIGAN STATE UNIVERSITY · PI SCHWARTZ, RICHARD C · 2015 to 2019
$4.1M
Metabolomics Administrative Supplement: Disruption of parity-induced tumor suppressor pathways by xenoestrogen exposures during pregnancyU01ES026140 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI JERRY, D. JOSEPH, SCHNEIDER, SALLIE SMITH · 2015 to 2019
$3.7M
NIEHS NIH HHS U01 ES026119NIEHS NIH HHS U01 ES026127NIEHS NIH HHS U01 ES026137NIEHS NIH HHS U01 ES026140
6 · The paper itself

Abstract

Environmental chemicals are a persistent and pervasive part of everyday life. A subset of environmental chemicals are xenoestrogens, compounds that bind to the estrogen receptor (ER) and drive estrogen-related processes. One such chemical, benzophenone-3 (BP3), is a common chemical in sunscreen. It is a potent UV protectant but also is quickly absorbed through the skin. While it has been approved by the FDA, there is a renewed interest in the safety of BP3, particularly in relation to breast cancer. The focus of this study was to examine the impact that BP3 has on triple negative breast cancer (TNBC) through alterations to cells in the immune microenvironment. In this study, we exposed female mice to one of two doses of BP3 before injecting them with a TNBC cell line. Several immune endpoints were examined both in the primary tissues and from

Identifiers

PMID37593105
PMCPMC10434833
OpenAlexW4310836696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.