Evidence map›Paper›PMID 37592998›Full record

ArticleChemical science2023

Comprehensive structural, infrared spectroscopic and kinetic investigations of the roles of the active-site arginine in bidirectional hydrogen activation by the [NiFe]-hydrogenase 'Hyd-2' from

Rhiannon M Evans, Stephen E Beaton, Patricia Rodriguez Macia, Yunjie Pang, Kin Long Wong, Leonie Kertess, William K Myers, Ragnar Bjornsson, Philip A Ash, Kylie A Vincent and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Genetic dissection of formate hydrogenlyase-2 function: a metalloenzyme involved in bacterial hydrogen production.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
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  3. ASH: A Multi-Scale, Multi-Theory Modeling Program.Journal of computational chemistry · 2026
    Article
  4. Lessons, connections, hypotheses and predictions from protein film electrochemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Stepwise conversion of the CysChemical science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Rhiannon M EvansUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-9549-4220
Stephen E BeatonUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.
Patricia Rodriguez MaciaUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0003-3513-0115
Yunjie PangCollege of Chemistry, Beijing Normal University 100875 Beijing China.
Kin Long WongUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-8479-2812
Leonie KertessUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0003-1470-3455
William K MyersUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0001-5935-9112
Ragnar BjornssonDepartment of Inorganic Spectroscopy, Max Planck Institute for Chemical Energy Conversion Stiftstraße 34-36 45470 Mülheim an der Ruhr Germany.ORCID https://orcid.org/0000-0003-2167-8374
Philip A AshSchool of Chemistry, The University of Leicester University Road Leicester LE1 7RH UK.ORCID https://orcid.org/0000-0001-5264-464X
Kylie A VincentUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0001-6444-9382
Stephen B CarrUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-1473-457X
Fraser A ArmstrongUniversity of Oxford, Department of Chemistry South Parks Road Oxford UK stephen.carr@rc-harwell.ac.uk fraser.armstrong@chem.ox.ac.uk.ORCID https://orcid.org/0000-0001-8041-2491
University of Oxford · GBRutherford Appleton Laboratory · GBBeijing Normal University · CNCentre National de la Recherche Scientifique · FRUniversity of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The active site of [NiFe]-hydrogenases contains a strictly-conserved pendant arginine, the guanidine head group of which is suspended immediately above the Ni and Fe atoms. Replacement of this arginine (R479) in hydrogenase-2 from

Identifiers

PMID37592998
PMCPMC10430524
OpenAlexW4385252199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.