Evidence map›Paper›PMID 37592860›Full record

Trial reportNeurorehabilitation and neural repair2023

Individual Differences in Response to Transcranial Direct Current Stimulation With Language Therapy in Subacute Stroke.

Melissa D Stockbridge, Jordan Elm, Abeba A Teklehaimanot, Christy Cassarly, Leigh-Ann Spell, Julius Fridriksson, Argye E Hillis

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02674490 (Effects of Transcranial Direct Current Stimulation), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02674490 nacompletednot on this map

Effects of Transcranial Direct Current Stimulation (tDCS) Plus Language Therapy for Naming in Subacute Left Hemisphere Stroke

TypeinterventionalSponsorJohns Hopkins UniversityRan2016 to 2022Enrolled58ConditionsStrokeArmsA-tDCS (1 mA), SALT, Sham
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Volumetric analysis of the damage and response of non-invasive brain stimulation in patients with spatial neglect after stroke: a subgroup analysis of the ELETRON trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Melissa D StockbridgeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9069-1236
Jordan ElmDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Abeba A TeklehaimanotDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Christy CassarlyDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Leigh-Ann SpellDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-6472-4249
Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5192-1171
Medical University of South Carolina · USJohns Hopkins University · USUniversity of South Carolina · US

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BONILHA, LEONARDO F · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Trans-cranial Direct Current Stimulation to Treat Aphasia: Phase II TrialU01DC011739 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2012 to 2016
$4.4M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS U01 DC011739NIH HHS S10 OD021648
6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) can be used to improve post-stroke aphasia. However, given the mixed evidence for its efficacy, individual differences may moderate the relative benefit of this strategy. In planned exploratory subgroup analyses, we examined whether age, education, sex, brain-derived neurotrophic factor status, and baseline performance individually impacted improvement in picture naming between baseline and 1 week after the end of the therapy, then whether the combination of factors that predicted recovery of naming and discourse differed for those who received concurrent tDCS.

objectiveExamine whether individual differences influenced the effect of tDCS on language recovery.

methodsIn this randomized, double-blind, sham-controlled, efficacy study of tDCS combined with language therapy for subacute post-stroke aphasia, patients completed an evaluation including the Philadelphia Naming Test and

resultsSignificant interactions were observed between tDCS group and both age and education. The predictors of a positive response to tDCS differed from the predictors of a positive response to language treatment alone. While baseline performance was an important predictor of future performance regardless of treatment group, responses to treatment without tDCS were influenced by age whereas responses to treatment with tDCS were not.

conclusionsAge and education influence the efficacy of different treatment strategies. Refinement of treatment selection is important to the overall individualization and optimization of post-stroke patient care.

trial registrationClinicalTrials.gov NCT02674490.

Indexed as

StrokeTranscranial Direct Current StimulationEducational StatusHumansIndividualityInfant, NewbornLanguage TherapyaphasiadiscoursenamingstroketDCS

Identifiers

PMID37592860
PMCPMC10528733
OpenAlexW4385969051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.