ArticleEuropean heart journal2023
End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre study.
Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- The Unnatural History of the Left Ventricle After Double Switch Operation for Congenitally Corrected Transposition of the Great Arteries with Intact Ventricular Septum: Dilation is the Norm.Pediatric cardiology · 2026Article
- Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries.Journal of the American Heart Association · 2026Article
- DragonFly™ edge-to-edge repair of the systemic atrioventricular valve in a patient with congenitally corrected transposition of the great arteries: a case report.European heart journal. Case reports · 2026Article
- Biventricular Pressure-Volume Area Ratio for the Assessment of Left Ventricular Preparedness for Double Switch Operation.JACC. Advances · 2026Article
- Recent advances in congenital heart disease with a systemic right ventricle: new insights for heart failure treatment from last EURO-ACHD Congress 2025.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Critical Care of the Adult With Congenital Heart Disease.JACC. Advances · 2025Review
- Implantable Defibrillator in the Systemic Right Ventricle: Are We Still Baffled?CJC pediatric and congenital heart disease · 2025Article
- Implantable Cardioverter-Defibrillator Therapy in Patients With Transposition of the Great Arteries: A Systematic Review of the Literature.CJC pediatric and congenital heart disease · 2025Review
- Analysis of Echocardiography and Risk Factors Related to Prognosis in Adult Patients with Isolated Congenitally Corrected Transposition of the Great Arteries.Journal of clinical medicine · 2025Article
- Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Systemic Right Ventricles: Incrementally Building the Evidence Base.Journal of the American Heart Association · 2025Article
- Safety and Efficacy of Dapagliflozin in Patients With Systemic Right Ventricular Dysfunction: DAPA-SRV Trial.Journal of the American Heart Association · 2025Observational
- Congenitally corrected transposition of the great arteries: one disease, diverse manifestations-a case series.European heart journal. Case reports · 2025Article
- Diagnosis, management, and outcome of heart failure in congenitally corrected transposition of the great arteries (ccTGA)-a narrative review.Cardiovascular diagnosis and therapy · 2025Review
- Stable Longitudinal Quality of Life in the SERVE Trial Among Adults With Transposition of the Great Arteries and a Systemic Right Ventricle.CJC pediatric and congenital heart disease · 2025Article
- Propensity Score Analysis of Possible Medication Effects on Outcomes in Patients With Systemic Right Ventricles.JACC. Advances · 2025Article
- Sacubitril/Valsartan and Dapagliflozin in Patients with a Failing Systemic Right Ventricle: Effects on the Arrhythmic Burden.Journal of clinical medicine · 2024Article
- Pathophysiology of the right ventricle and its pulmonary vascular interaction.The European respiratory journal · 2024Review
- Towards Understanding Deterioration in Systemic Right Ventricular Function in the Setting of Tricuspid Regurgitation: Is There a Point of No Return?CJC pediatric and congenital heart disease · 2024Article
- Tricuspid Regurgitation Stratification Predicts the Time Course of Systemic Right Ventricle Dysfunction Among Patients on ACE-I/ARB.CJC pediatric and congenital heart disease · 2024Article
- Pathogenesis and Surgical Treatment of Congenitally Corrected Transposition of the Great Arteries (ccTGA): Part III.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 9 countries.
Funding
Abstract
BACKGROUND AND
aimsFor patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear.
methodsThis multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained. The composite primary outcome was mechanical circulatory support, heart transplantation, or death.
resultsFrom 558 patients (48% female, age at first visit 36 ± 14.2 years, median follow-up 8.7 years), the event rate of the primary outcome was 15.4 per 1000 person-years (11 mechanical circulatory support implantations, 12 transplantations, and 52 deaths). Patients experiencing the primary outcome were older and more likely to have a history of atrial arrhythmia. The primary outcome was highest in those with both moderate/severe right ventricular (RV) dysfunction and tricuspid regurgitation (n = 110, 31 events) and uncommon in those with mild/less RV dysfunction and tricuspid regurgitation (n = 181, 13 events, P < .001). Outcomes were not different based on anatomic complexity and history of tricuspid valve surgery or of subpulmonic obstruction. New CHF admission or ventricular arrhythmia was associated with the primary outcome. Individuals who underwent childhood surgery had more adverse outcomes than age- and sex-matched controls. Multivariable Cox regression analysis identified older age, prior CHF admission, and severe RV dysfunction as independent predictors for the primary outcome.
conclusionsPatients with ccTGA have variable deterioration to end-stage heart failure or death over time, commonly between their fifth and sixth decades. Predictors include arrhythmic and CHF events and severe RV dysfunction but not anatomy or need for tricuspid valve surgery.
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