ArticleBiology direct2023
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity.
Article in Biology direct, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A single-cell transcriptome atlas reveals paradoxical monoallelic expression of RNA editing and heterozygous SNPs.Nucleic acids research · 2026Article
- A-to-I mRNA editing: Why not simply incorporate inosine during mRNA synthesis?Molecular biology reports · 2026Review
- The neuronal A-to-I RNA editome of Solenopsis invicta expands conserved recoding repertoire between two ant species.BMC genomics · 2026Article
- Different mRNAs encoding identical proteins: how and why?Journal of applied genetics · 2026Article
- Abundant A-to-I RNA editing in spermatocytes may suppress transposons to compensate for piRNA downregulation in male germlines.RNA biology · 2025Article
- Article
- Fascination with RNA Editing: In the Lights of Evolution and Biology.Journal of molecular evolution · 2025Review
- On the origin, evolution, and maintenance of RNA editing.Nucleic acids research · 2025Review
- Promiscuous RNA editing in lncRNARNA (New York, N.Y.) · 2025Article
- Signal peptides restrict genome evolution and A-to-I RNA editing.NAR genomics and bioinformatics · 2025Article
- Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C.Epigenomics · 2025Article
- Systematic revelation and meditation on the significance of long exons using representative eukaryotic genomes.BMC genomics · 2025Article
- On the reversibility of RNA deamination versus RNA methylation: exploring the proximate and ultimate causes.Journal of genetics · 2025Review
- Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insectEpigenetics · 2024Article
- Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts.Nucleus (Austin, Tex.) · 2024Article
- Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations.Journal of applied genetics · 2024Article
- Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects.BMC genomics · 2024Article
- Comparative genomic analyses on assassin bugiScience · 2024Article
- RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics.iScience · 2024Article
- New comparative genomic evidence supporting the proteomic diversification role of A-to-I RNA editing in insects.Molecular genetics and genomics : MGG · 2024Article
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6 authors.
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Abstract
backgroundC-to-U RNA editing in plants is believed to confer its evolutionary adaptiveness by reversing unfavorable DNA mutations. This "restorative hypothesis" has not yet been tested genome-wide. In contrast, A-to-I RNA editing in insects like Drosophila and honeybee is already known to benefit the host by increasing proteomic diversity in a spatial-temporal manner (namely "diversifying hypothesis").
methodsWe profiled the RNA editomes of multiple tissues of Arabidopsis thaliana, Drosophila melanogaster, and Apis melifera. We unprecedentedly defined the haplotype diversity (HD) of RNA molecules based on nonsynonymous editing events (recoding sites).
resultsSignals of adaptation is confirmed in Arabidopsis by observing higher frequencies and levels at nonsynonymous editing sites over synonymous sites. Compared to A-to-I recoding sites in Drosophila, the C-to-U recoding sites in Arabidopsis show significantly lower HD, presumably due to the stronger linkage between C-to-U events.
conclusionsC-to-U RNA editing in Arabidopsis is adaptive but it is not designed for diversifying the proteome like A-to-I editing in Drosophila. Instead, C-to-U recoding sites resemble DNA mutations. Our observation supports the restorative hypothesis of plant C-to-U editing which claims that editing is used for fixing unfavorable genomic sequences.
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