Evidence map›Paper›PMID 37592310›Full record

Trial reportFluids and barriers of the CNS2023

Relationship between brain iron dynamics and blood-brain barrier function during childhood: a quantitative magnetic resonance imaging study.

Yuto Uchida, Hirohito Kan, Gen Furukawa, Kengo Onda, Keita Sakurai, Koji Takada, Noriyuki Matsukawa, Kenichi Oishi

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Fluids and barriers of the CNS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. The role of autoantibodies in Alzheimer's disease: Pathogenetic connections or epiphenomena?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuto UchidaDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 208 Traylor Building, 720 Rutland Avenue, Baltimore, MD, 21205, USA. yuchida2@jhmi.edu.
Hirohito KanDepartment of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1- 1-20, Daiko-Minami, Higashi-ku, Nagoya, 461-8673, Aichi, Japan.
Gen FurukawaDepartment of Pediatrics, Fujita Health University School of Medicine, 1-98, Kutsukake-cho, Dengakugakubo, Toyoake, 470-1192, Aichi, Japan.
Kengo OndaDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 208 Traylor Building, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Keita SakuraiDepartment of Radiology, National Center for Geriatrics and Gerontology, Morioka-cho, Obu, 474-8511, Aichi, Japan.
Koji TakadaDepartment of Neurology, Toyokawa City Hospital, 23, Noji, Yawata-cho, Toyokawa, 442-0857, Aichi, Japan.
Noriyuki MatsukawaDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Aichi, Japan.
Kenichi OishiDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 208 Traylor Building, 720 Rutland Avenue, Baltimore, MD, 21205, USA.

Funding

Japan Society for the Promotion of Science 22K07520
6 · The paper itself

Abstract

backgroundMounting evidence suggests that the blood-brain barrier (BBB) plays an important role in the regulation of brain iron homeostasis in normal brain development, but these imaging profiles remain to be elucidated. We aimed to establish a relationship between brain iron dynamics and BBB function during childhood using a combined quantitative magnetic resonance imaging (MRI) to depict both physiological systems along developmental trajectories.

methodsIn this single-center prospective study, consecutive outpatients, 2-180 months of age, who underwent brain MRI (3.0-T scanner; Ingenia; Philips) between January 2020 and January 2021, were included. Children with histories of preterm birth or birth defects, abnormalities on MRI, and diagnoses that included neurological diseases during follow-up examinations through December 2022 were excluded. In addition to clinical MRI, quantitative susceptibility mapping (QSM; iron deposition measure) and diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL; BBB function measure) were acquired. Atlas-based analyses for QSM and DP-pCASL were performed to investigate developmental trajectories of regional brain iron deposition and BBB function and their relationships.

resultsA total of 78 children (mean age, 73.8 months ± 61.5 [SD]; 43 boys) were evaluated. Rapid magnetic susceptibility progression in the brain (Δsusceptibility value) was observed during the first two years (globus pallidus, 1.26 ± 0.18 [× 10

conclusionsThe combined quantitative MRI study of QSM and DP-pCASL for pediatric brains demonstrated the relationship between brain iron dynamics and BBB function during childhood.

trial registrationUMIN Clinical Trials Registry identifier: UMIN000039047, registered January 6, 2020.

Indexed as

Blood-Brain BarrierPremature BirthBrainChildFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaleProspective StudiesBlood–brain barrierDiffusion-prepared pseudo-continuous arterial spin labelingMagnetic resonance imagingPediatric brainQuantitative susceptibility mapping

Identifiers

PMID37592310
PMCPMC10433620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.