SynthesisBMC surgery2023
The impact of sarcopenia on esophagectomy for cancer: a systematic review and meta-analysis.
Synthesis in BMC surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Post-esophagectomy hiatal hernias: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2026Pooled it
- Predictive role of preoperative sarcopenia for long-term survival in rectal cancer patients: A meta-analysis.PloS one · 2024Pooled it
- Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Masseter muscle change during chemoradiotherapy for esophageal cancer: survival and immunonutritional associations compared with the psoas muscle index.Surgery today · 2026Article
- Comparative clinical utility of preoperative psoas muscle and skeletal muscle index cutoffs for risk stratification after esophagectomy.Surgery today · 2026Article
- Article
- Association of Preoperative Inspiratory Muscle Weakness and Respiratory Sarcopenia with Postoperative Pneumonia Following Esophagectomy: A Multicenter Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- Impact of Preoperative Sarcopenia on Patient Survival After Esophagectomy for Cancer: A Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- Preoperative Physiological Reserve and Pathological Response as Independent Predictors of Survival in Esophageal Squamous Cell Carcinoma after Neoadjuvant Therapy.Annals of surgical oncology · 2026Article
- Nomographic predictive models for complications after minimally invasive esophagectomy: Current status and future perspectives.World journal of gastrointestinal surgery · 2025Review
- Response to a prehabilitation program for patients with oesophageal cancer: an observational study.Perioperative medicine (London, England) · 2025Article
- The Influence of Muscle Morphology on Oncological Outcomes: A Review.Journal of frailty, sarcopenia and falls · 2025Review
- Sarcopenia worsens overall survival following robotic esophagectomy for esophageal cancer.Scientific reports · 2025Article
- Effects of respiratory sarcopenia on the postoperative course in elderly lung cancer patient: a retrospective study.Journal of cardiothoracic surgery · 2025Article
- Article
- Long-term outcomes of endoscopic resection of superficial esophageal squamous cell carcinoma in late-elderly patients.Journal of gastroenterology and hepatology · 2024Article
- Best Practices for Managing Patients with Unresectable Metastatic Gastric and Gastroesophageal Junction Cancer in Canada.Current oncology (Toronto, Ont.) · 2024Review
- Psoas muscle mass index and peak expiratory flow as measures of sarcopenia: relation to outcomes of elderly patients with resectable esophageal cancer.Frontiers in oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophagectomy is the gold-standard treatment for locally advanced esophageal cancer but has high morbimortality rates. Sarcopenia is a common comorbidity in cancer patients. The exact burden of sarcopenia in esophagectomy outcomes remains unclear. Therefore, this systematic review and meta-analysis were performed to establish the impact of sarcopenia on postoperative outcomes of esophagectomy for cancer.
methodsWe performed a systematic review and meta-analysis comparing sarcopenic with non-sarcopenic patients before esophagectomy for cancer (Registration number: CRD42021270332). An electronic search was conducted on Embase, PubMed, Cochrane, and LILACS, alongside a manual search of the references. The inclusion criteria were cohorts, case series, and clinical trials; adult patients; studies evaluating patients with sarcopenia undergoing esophagectomy or gastroesophagectomy for cancer; and studies that analyze relevant outcomes. The exclusion criteria were letters, editorials, congress abstracts, case reports, reviews, cross-sectional studies, patients undergoing surgery for benign conditions, and animal studies. The meta-analysis was synthesized with forest plots.
resultsThe meta-analysis included 40 studies. Sarcopenia was significantly associated with increased postoperative complications (RD: 0.08; 95% CI: 0.02 to 0.14), severe complications (RD: 0.11; 95% CI: 0.04 to 0.19), and pneumonia (RD: 0.13; 95% CI: 0.09 to 0.18). Patients with sarcopenia had a lower probability of survival at a 3-year follow-up (RD: -0.16; 95% CI: -0.23 to -0.10).
conclusionPreoperative sarcopenia imposes a higher risk for overall complications and severe complications. Besides, patients with sarcopenia had a lower chance of long-term survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.