Evidence map›Paper›PMID 37592141›Full record

ArticleRheumatology international2023

Mycophenolate mofetil may be an alternative for maintenance therapy of Behçet syndrome uveitis: a single-center retrospective analysis.

Didar Ucar, Sinem Nihal Esatoglu, Emir Cerme, Bilge Batu-Oto, Vedat Hamuryudan, Emire Seyahi, Melike Melikoglu, Izzet Fresko, Yılmaz Ozyazgan, Gulen Hatemi

Abstract read
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In one paragraph

Article in Rheumatology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Can mycophenolate mofetil be an effective option in the treatment of vascular Behçet's Syndrome.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  3. Review
  4. Behçet syndrome with eye involvement.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Didar UcarDepartment of Ophthalmology, Cerrahpaşa Medical Faculty Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-3469-7307
Sinem Nihal EsatogluBehçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey. nihalesatoglu@gmail.com.ORCID http://orcid.org/0000-0001-5414-7305
Emir CermeDivision of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-8263-0692
Bilge Batu-OtoDepartment of Ophthalmology, Cerrahpaşa Medical Faculty Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-9729-2577
Vedat HamuryudanBehçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-6625-1652
Emire SeyahiBehçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-4965-2918
Melike MelikogluBehçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-0253-8368
Izzet FreskoBehçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-8914-9690
Yılmaz OzyazganDepartment of Ophthalmology, Cerrahpaşa Medical Faculty Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-0555-768X
Gulen HatemiBehçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1952-1135
Istanbul University-Cerrahpaşa · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experience with mycophenolate in uveitis due to Behçet syndrome (BS) is limited. Twelve patients with panuveitis or posterior uveitis who were started mycophenolate were included. Data on demographic characteristics, therapies, ocular attacks, and adverse events were extracted from patient charts. Seven patients with BS uveitis were prescribed mycophenolate for remission induction, of which 6 were refractory/intolerant to conventional immunosuppressives. Mycophenolate was combined with anti-TNFs in 3 patients, resulting in no further ocular attacks. Mycophenolate had to be stopped in the fourth patient due to adverse events. The remaining 3 patients continued to have ocular attacks and were switched to other agents without any drop in visual acuity. Among the 5 patients who were prescribed mycophenolate for maintenance, 2 were relapse free, but 3 experienced ocular attacks. One patient had an exacerbation of mucocutaneous lesions, and 2 experienced adverse events. Mycophenolate monotherapy may not be adequate for remission induction of refractory BS uveitis, but it can be a safe and effective alternative when combined with a biologic agent. It may also be an option for maintenance therapy.

Indexed as

Behcet SyndromeUveitisHumansImmunosuppressive AgentsMycophenolic AcidRetrospective StudiesImmunosuppressive AgentsMycophenolic AcidBehçet syndromeEye involvementMycophenolateTreatmentUveitis

Identifiers

PMID37592141
OpenAlexW4385955649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.