Evidence map›Paper›PMID 37592059›Full record

Trial reportInternational journal of obesity (2005)2023

Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood.

Elina Blanco Sequeiros, Anna-Kaisa Tuomaala, Rubina Tabassum, Paula H Bergman, Saila B Koivusalo, Emilia Huvinen

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01698385 (Prevention of Gestational Diabetes Through Lifestyle Modification), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01698385 nacompletednot on this map

Prevention of Gestational Diabetes Through Lifestyle Modification (RADIEL) - a Randomized Controlled Multi-centre Intervention Study

TypeinterventionalSponsorHelsinki University Central HospitalRan2008 to 2014Enrolled750ConditionsGestational DiabetesArmsDiet and exercise counseling
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elina Blanco SequeirosUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland. ebs@soite.fi.ORCID 0009-0007-4797-2869
Anna-Kaisa TuomaalaDepartment of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Rubina TabassumInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Paula H BergmanBiostatistics Consulting, Department of Public Health, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Saila B Koivusalo *Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0002-9482-9826
Emilia Huvinen *Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-2788-1947
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntrauterine conditions and accelerating early growth are associated with childhood obesity. It is unknown, whether fetal programming affects the early growth and could alterations in the maternal-fetal metabolome be the mediating mechanism. Therefore, we aimed to assess the associations between maternal and cord blood metabolite profile and offspring early growth.

methodsThe RADIEL study recruited 724 women at high risk for gestational diabetes mellitus (GDM) BMI ≥ 30 kg/m

resultsFrom the cohort of mother-child dyads with available growth profile data (n = 572), we have metabolomic data from 232 mothers from 1st trimester, 271 from 2nd trimester, 277 from 3rd trimester and 345 from cord blood. We have data on 220 metabolites in each trimester and 70 from cord blood. In each trimester of pregnancy, the mothers of the ascending group showed higher levels of VLDL and LDL particles, and lower levels of HDL particles (p < 0.05). When adjusted for gestational age, birth weight, sex, delivery mode, and maternal smoking, there was an association with ascending profile and 2nd trimester total cholesterol in HDL2, 3rd trimester total cholesterol in HDL2 and in HDL, VLDL size and ratio of triglycerides to phosphoglycerides (TG/PG ratio) in cord blood (p ≤ 0.002).

conclusionAscending early growth was associated with lower maternal total cholesterol in HDL in 2nd and 3rd trimester, and higher VLDL size and more adverse TG/PG ratio in cord blood. CLINICAL

trial registrationClinicalTrials.gov, http://www. CLINICALTRIALS: com , NCT01698385.

Indexed as

Diabetes, GestationalPediatric ObesityChildCholesterolFemaleFetal BloodHumansLipoproteinsPregnancyCholesterolLipoproteins

Identifiers

PMID37592059
PMCPMC10599999
OpenAlexW4385950079

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.