ArticleNature neuroscience2023
Orbitofrontal cortex control of striatum leads economic decision-making.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior.Neuron · 2026Article
- Population geometries in frontal cortex coordinate value-based decisions.bioRxiv : the preprint server for biology · 2026Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- Orbitofrontal Cortex Encodes Decision Signals during Value-based But Not Perceptual Decisions.Journal of cognitive neuroscience · 2026Article
- The Laminar Organization of a Decision Circuit in Orbitofrontal Cortex is Agnostic to the Variable Encoding Scheme.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Genoarchitecture and input-output organization of the mouse basal ganglia and thalamic parafascicular nucleus.Nature neuroscience · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Submedius thalamic inputs shape the presynaptic architecture of layer 5 orbitofrontal cortex in mice.iScience · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.bioRxiv : the preprint server for biology · 2025Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning.Nature communications · 2025Article
- Article
- Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum.Science advances · 2025Article
- Theoretical analysis of low-power deep synergistic sono-optogenetic excitation of neurons by co-expressing light-sensitive and mechano-sensitive ion-channels.Communications biology · 2025Article
- Anatomical mapping of whole-brain monosynaptic inputs to the orbitofrontal cortex.Frontiers in neural circuits · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain regions have been individually implicated in these processes, the brain-wide mechanisms relating these regions in decision-making are unclear. Using an economic decision-making task adapted for rats, we find that neural activity in both of two connected brain regions, the ventrolateral orbitofrontal cortex (OFC) and the dorsomedial striatum (DMS), was required for economic decision-making. Relevant neural activity in both brain regions was strikingly similar, dominated by the spatial features of the decision-making process. However, the neural encoding of choice direction in OFC preceded that of DMS, and this temporal relationship was strongly correlated with choice accuracy. Furthermore, activity specifically in the OFC projection to the DMS was required for appropriate economic decision-making. These results demonstrate that choice information in the OFC is relayed to the DMS to lead accurate economic decision-making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.