Decreased adhesion to endothelium leads to elevated neutrophil granulocyte count in hereditary angioedema patients.

Erika Kajdácsi, Zsuzsanna Balla, Zsófia Pólai, László Cervenak, Henriette Farkas

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In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erika KajdácsiResearch Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Szentkirályi u. 46., Budapest, 1088, Hungary. kajdacsi.erika@med.semmelweis-univ.hu.

Zsuzsanna BallaHungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.

Zsófia PólaiResearch Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Szentkirályi u. 46., Budapest, 1088, Hungary.

László CervenakResearch Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Szentkirályi u. 46., Budapest, 1088, Hungary.

Henriette FarkasResearch Laboratory, Department of Internal Medicine and Haematology, Semmelweis University, Szentkirályi u. 46., Budapest, 1088, Hungary.

Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As many aspects of hereditary angioedema (HAE) due to C1-inhibitor (C1-INH) deficiency (C1-INH-HAE) cannot be explained with elevated bradykinin level alone, it has recently become clear that other factors also play an important role in the pathogenesis. One of these factors could be elevated neutrophil granulocyte (NG) counts, which are associated with increased NG activation in C1-INH-HAE patients; however, their origin has not been elucidated so far. Here, we aimed to investigate whether the excess of NGs is due to disturbed maturation, biased circulating/marginated pool equilibrium or decreased elimination. We enrolled 20 attack-free C1-INH-HAE patients together with 21 healthy controls and collected blood samples. We compared cell surface maturation markers, adhesion molecules, cytokine receptors, and Ca

Indexed as

Angioedemas, HereditaryNeutrophilsBradykininEndothelial CellsEndotheliumGranulocytesHumansBradykinin

Identifiers

PMID37591965

DOI10.1002/clt2.12135

PMCPMC10435475

OpenAlexW4385954219

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Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.