Evidence map›Paper›PMID 37591873›Full record

ArticleBlood cancer journal2023

T-cell phenotype including CD57

Zhi-Zhang Yang, Hyo Jin Kim, Hongyan Wu, Xinyi Tang, Yue Yu, Jordan Krull, Daniel P Larson, Raymond M Moore, Matthew J Maurer, Kevin D Pavelko and 8 more

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Zhi-Zhang YangDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. yang.zhizhang@mayo.edu.ORCID http://orcid.org/0000-0002-1468-2300
Hyo Jin KimDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Hongyan WuDepartment of Immunology, Medical College, China Three Gorges University, Yichang, Hubei, China.
Xinyi TangDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Yue YuDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jordan KrullDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6507-8085
Daniel P LarsonDepartment of Pathology, Mayo Clinic, Rochester, MN, USA.
Raymond M MooreDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Matthew J MaurerDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1867-0526
Kevin D PavelkoDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7555-1315
Shahrzad JalaliDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Joshua C PritchettDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Rekha MudappathiDepartment of Quantitative Health Sciences and center for Individual Medicine, Mayo Clinic, Scottsdale, AZ, USA.ORCID http://orcid.org/0000-0001-7965-0919
Junwen WangDepartment of Quantitative Health Sciences and center for Individual Medicine, Mayo Clinic, Scottsdale, AZ, USA.ORCID http://orcid.org/0000-0002-4432-4707
Jose C VillasboasDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2907-0809
Patrizia MondelloDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Anne J NovakDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-7904-1651
Stephen M AnsellDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. ansell.stephen@mayo.edu.ORCID http://orcid.org/0000-0003-1244-6758
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · USChina Three Gorges University · CN

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
NCI NIH HHS P50 CA097274
6 · The paper itself

Abstract

T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We identified four immune subgroups with differing T-cell phenotypes and the prevalence of certain T-cell subsets was associated with patient survival. Patients with increased T cells with early differentiation stage tended to have a significantly better survival than patients with increased T-cells of late differentiation stage. Specifically, CD57

Indexed as

Lymphoma, FollicularT Follicular Helper CellsCell DifferentiationHumansPhenotypeTumor Microenvironment

Identifiers

PMID37591873
PMCPMC10435479
OpenAlexW4385969652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.