ArticleNature communications2023
Sustainable production of dopamine hydrochloride from softwood lignin.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 76 citations in OpenAlex.
- Photocatalytic Lignin Depolymerization and Cross-Coupling With Alcohols to Produce Unsymmetric Aromatic Diols.Angewandte Chemie (International ed. in English) · 2026Article
- A Fully Bio-Based Elastomer with Ultrahigh Lignin Content and Performance Rivaling Nitrile Rubber.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Beyond neurotransmission: dopamine as an emerging biotic and abiotic stress regulator in plants.Stress biology · 2026Review
- Pathway crosstalk enables degradation of aromatic compounds in marineApplied and environmental microbiology · 2025Article
- Article
- A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application.Journal of nanobiotechnology · 2025Review
- The knowledge driven DBTL cycle provides mechanistic insights while optimising dopamine production in Escherichia coli.Microbial cell factories · 2025Article
- Producing aryl halides from lignin.Nature communications · 2025Article
- Modulating product selectivity in lignin electroreduction with a robust metallic glass catalyst.Nature communications · 2025Article
- Integrated process for lignin depolymerization and nanoparticle production using deep eutectic solvent.Scientific reports · 2025Article
- Photothermal catalytic transfer hydrogenolysis of protolignin.Nature communications · 2024Article
- Benzenoid Aromatics from Renewable Resources.Chemical reviews · 2024Review
- Lattice Strain Engineering on Metal-Organic Frameworks by Ligand Doping to Boost the Electrocatalytic Biomass Valorization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Blue valorization of lignin-derived monomers via reprogramming marine bacteriumApplied and environmental microbiology · 2024Article
- Review
- Aqueous amine enables sustainable monosaccharide, monophenol, and pyridine base coproduction in lignocellulosic biorefineries.Nature communications · 2024Article
- Computer-aided design and implementation of efficient biosynthetic pathways to produce high added-value products derived from tyrosine inFrontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine is not only a widely used commodity pharmaceutical for treating neurological diseases but also a highly attractive base for advanced carbon materials. Lignin, the waste from the lignocellulosic biomass industry, is the richest source of renewable aromatics on earth. Efficient production of dopamine direct from lignin is a highly desirable target but extremely challenging. Here, we report an innovative strategy for the sustainable production of dopamine hydrochloride from softwood lignin with a mass yield of 6.4 wt.%. Significantly, the solid dopamine hydrochloride is obtained by a simple filtration process in purity of 98.0%, which avoids the tedious separation and purification steps. The approach begins with the acid-catalyzed depolymerization, followed by deprotection, hydrogen-borrowing amination, and hydrolysis of methoxy group, transforming lignin into dopamine hydrochloride. The technical economic analysis predicts that this process is an economically competitive production process. This study fulfills the unexplored potential of dopamine hydrochloride synthesis from lignin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.