ReviewNature reviews. Disease primers2023
HIV infection.
Review in Nature reviews. Disease primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06250881 (Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation), which is not on this map. Cited by 135 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation
Who cites it
135 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Clinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis.European journal of drug metabolism and pharmacokinetics · 2026Pooled it
- Unveiling the underestimated prevalence of HIV, HBV and TB triple infection in Asia, South America, and Africa: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Developing an HIV-specific falls risk prediction model with a novel clinical index: a systematic review and meta-analysis method.BMC infectious diseases · 2024Pooled it
- Cancer risk in people living with HIV and solid organ transplant recipients: a systematic review and meta-analysis.The Lancet. Oncology · 2024Pooled it
- Inadequate immune response to inactivated COVID-19 vaccine among older people living with HIV: a prospective cohort study.Journal of virology · 2025Trial
- Harnessing conserved epitopes and multivalent antigen strategies for vaccine design: Lessons learned and opportunities.Human vaccines & immunotherapeutics · 2026Review
- HIV cure: from early therapies to cutting-edge strategies.Journal of neurovirology · 2026Review
- Design of an immunogen containing multidimensionally conserved and immunogenic parts of the HIV proteome.PLoS computational biology · 2026Article
- Lathyrane Diterpenoids: Half-Century of Chemical Insights and Therapeutic Potential.Plants (Basel, Switzerland) · 2026Review
- Crosstalk of thioredoxin system and programmed cell death: from pathophysiology to novel therapy.Redox biology · 2026Review
- Metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated alcohol-related liver disease in human immunodeficiency virus.World journal of virology · 2026Review
- The role of DPP4 in viral infections: from receptor biology to antiviral target.Archives of virology · 2026Review
- Single-cell characterization of the CD8Virology journal · 2026Article
- NADThe Journal of general virology · 2026Review
- High Prevalence of and Low Testing for Sexually Transmitted Infections Among Transgender Women in Cali, Colombia.Sexually transmitted diseases · 2026Article
- Detailed HIV Self-Testing Patterns Derived from Paradata in the mLab App Clinical Trial.AIDS and behavior · 2026Article
- The Gut-Immune Axis in Treated HIV Infection: From Mucosal Damage to Chronic Inflammation and Therapeutic Opportunities-A Clinician-Oriented Narrative Review.Microorganisms · 2026Review
- Prediction Models for Frailty in People Living With HIV: Protocol for a Systematic Review and Meta-Analysis of Prognostic Models.JMIR research protocols · 2026Article
- Discovering novel multi-target compounds against aspartyl viral polymerases via ligand-based pharmacophore and structure-based screening.Scientific reports · 2026Article
- HIV-1 Vif-dependent SUMOylation regulates viral RNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
The AIDS epidemic has been a global public health issue for more than 40 years and has resulted in ~40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted via body fluids and secretions. After infection, the virus invades host cells by attaching to CD4 receptors and thereafter one of two major chemokine coreceptors, CCR5 or CXCR4, destroying the host cell, most often a T lymphocyte, as it replicates. If unchecked this can lead to an immune-deficient state and demise over a period of ~2-10 years. The discovery and global roll-out of rapid diagnostics and effective antiretroviral therapy led to a large reduction in mortality and morbidity and to an expanding group of individuals requiring lifelong viral suppressive therapy. Viral suppression eliminates sexual transmission of the virus and greatly improves health outcomes. HIV infection, although still stigmatized, is now a chronic and manageable condition. Ultimate epidemic control will require prevention and treatment to be made available, affordable and accessible for all. Furthermore, the focus should be heavily oriented towards long-term well-being, care for multimorbidity and good quality of life. Intense research efforts continue for therapeutic and/or preventive vaccines, novel immunotherapies and a cure.
Indexed as
Identifiers
37591865What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.