ArticleNature communications2023
The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The basal ganglia and the epilepsies.Epilepsia open · 2026Review
- Similar Response Dynamics Represent Opposite Behaviors and Rewards in the Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- An ultrasound-scanning in vivo light source.Nature materials · 2026Article
- Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ channel dysfunction, hyperexcitability and ASD-like behaviours.Cellular and molecular life sciences : CMLS · 2026Article
- Editorial: Updates and discussions about basal ganglia and their circuits.Frontiers in neuroanatomy · 2026Article
- Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Neurodegenerative Disease Movement Disorders and Dorsal Striatum-Mediated Imbalance of Habitual Motor Sequences.Molecular neurobiology · 2025Review
- Nanoscale synaptic remodeling at corticostriatal circuits predicts flexible action control.bioRxiv : the preprint server for biology · 2025Article
- The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum.Molecular brain · 2025Article
- From avoidance to new action: the multifaceted role of the striatal indirect pathway.Nature reviews. Neuroscience · 2025Review
- Similar Dynamic Frontal Cortex Representations of Auditory Stimuli Cueing Opposite Actions and Rewards.bioRxiv : the preprint server for biology · 2025Article
- Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making.Science advances · 2025Article
- Article
- Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion.bioRxiv : the preprint server for biology · 2024Article
- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs.Nature neuroscience · 2024Article
- Article
- Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.Nature communications · 2024Article
- Striatal insights: a cellular and molecular perspective on repetitive behaviors in pathology.Frontiers in cellular neuroscience · 2024Review
- Compensatory Processes in Striatal Neurons Expressing the Tyrosine Hydroxylase Gene in Transgenic Mice in a Model of Parkinson's Disease.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basal ganglia are known to control actions and modulate movements. Neuronal activity in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral control. Previous evidence has led to divergent conclusions on the respective engagement of both pathways during actions. Using calcium imaging to evaluate how neurons in the direct and indirect pathways encode behaviors during self-paced spontaneous explorations in an open field, we observed that the two striatal pathways exhibit distinct tuning properties. Supervised learning algorithms revealed that direct pathway neurons encode behaviors through their activation, whereas indirect pathway neurons exhibit behavior-specific silencing. These properties remain stable for weeks. Our findings highlight a complementary encoding of behaviors with congruent activations in the direct pathway encoding multiple accessible behaviors in a given context, and in the indirect pathway encoding the suppression of competing behaviors. This model reconciles previous conflicting conclusions on motor encoding in the striatum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.