Evidence map›Paper›PMID 37591734›Full record

ArticleeNeuro2023

Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons.

Vanessa Osman, Iris Speigel, Kishan Patel, Hugh C Hemmings

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Isoflurane causes muscle contraction inmicroPublication biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vanessa OsmanDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065.
Iris SpeigelDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY 10065.
Kishan PatelDepartment of Anesthesiology, Weill Cornell Medical College, New York, NY 10065.
Hugh C HemmingsDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065 hchemmi@med.cornell.edu.
Cornell University · US

Funding

SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTIONR01GM058055 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMMINGS, HUGH C · 1998 to 2023
$10.1M
The Effect of Isoflurane on Axonal Endoplasmic Reticulum Ca2+ Dynamics in Hippocampal NeuronsF31GM133115 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI OSMAN, VANESSA · 2019 to 2021
$137k
NIGMS NIH HHS F31 GM133115NIGMS NIH HHS R01 GM058055
6 · The paper itself

Abstract

Volatile anesthetics reduce excitatory synaptic transmission by both presynaptic and postsynaptic mechanisms which include inhibition of depolarization-evoked increases in presynaptic Ca

Indexed as

IsofluraneMalignant HyperthermiaAnimalsCalciumEndoplasmic ReticulumHippocampusMiceNeuronsRatsRodentiaRyanodine Receptor Calcium Release ChannelCalciumIsofluraneRyanodine Receptor Calcium Release Channelanesthesiacalciumendoplasmic reticulumexocytosisisofluranemalignant hyperthermiapresynapticpropofolsevofluranesynaptic vesicle

Identifiers

PMID37591734
PMCPMC10467020
OpenAlexW4385932438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.