Evidence map›Paper›PMID 37591648›Full record

ArticleBMJ open2023

WHO O2CoV2: oxygen requirements and respiratory support in patients with COVID-19 in low-and-middle income countries-protocol for a multicountry, prospective, observational cohort study.

Pryanka Relan, Srinivas Murthy, John C Marshall, Djillali Annane, Sylvie Chevret, Yaseen M Arabi, Wangari Waweru-Siika, Sara Dominguez Rodriguez, Pauline Convocar, Janet Diaz and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04918875 (Oxygen Requirements and Approaches to Respiratory Support in Patients With COVID-19 in LMICs), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04918875 unknown statusnot on this map

Oxygen Requirements and Approaches to Respiratory Support in Patients With COVID-19 in LMICs: A WHO Study

TypeobservationalSponsorPryanka RelanRan2022 to 2023Enrolled2,400ConditionsCovid19, COVID-19 Pneumonia
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pryanka RelanWorld Health Organization, Geneva, Switzerland pryanka.relan@gmail.com.ORCID 0000-0002-9543-7891
Srinivas MurthyUniversity of British Columbia, Vancouver, British Columbia, Canada.
John C MarshallUniversity of Toronto, Toronto, Ontario, Canada.
Djillali AnnaneIHU PROMETHEUS, General ICU, Raymond Poincaré Hospital, University Paris Saclay campus Versailles, APHP, Garches, France.ORCID 0000-0001-6805-8944
Sylvie ChevretUMR1153, Université Paris Cité and INSERM, Paris, France.
Yaseen M ArabiKing Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID 0000-0001-5735-6241
Wangari Waweru-SiikaAga Khan University (AKU), Nairobi, Kenya.
Sara Dominguez RodriguezWorld Health Organization, Geneva, Switzerland.
Pauline ConvocarCorazon Locsin Montelibano Memorial Medical Hospital, Manila Doctors Hospital, Southern Philippines Medical Center, Manila, Philippines.
Janet DiazWorld Health Organization, Geneva, Switzerland.
World Health Organization Respiratory Support Research Group
World Health Organization O2CoV2 International Study Steering Committee

Funding

World Health Organization 001
6 · The paper itself

Abstract

introductionSARS-CoV-2 has been identified as the cause of the disease officially named COVID-19, primarily a respiratory illness. COVID-19 was characterised as a pandemic on 11 March 2020. It has been estimated that approximately 20% of people with COVID-19 require oxygen therapy. Oxygen has been listed on the WHO Model List of Essential Medicines List and Essential Medicines List for Children for almost two decades. The COVID-19 pandemic has highlighted, more than ever, the acute need for scale-up of oxygen therapy. Detailed data on the use of oxygen therapy in low-and-middle income countries at the patient and facility level are needed to target interventions better globally. METHODS AND ANALYSIS: We aim to describe the requirements and use of oxygen at the facility and patient level of approximately 4500 patients with COVID-19 in 30 countries. Our objectives are specifically to characterise type and duration of different modalities of oxygen therapy delivered to patients; describe demographics and outcomes of hospitalised patients with COVID-19; and describe facility-level oxygen production and support. Primary analyses will be descriptive in nature. Respiratory support transitions will be described in Sankey plots, and Kaplan-Meier models will be used to estimate probability of each transition. A multistate model will be used to study the course of hospital stay of the study population, evaluating transitions of escalating respiratory support transitions to the absorbing states. ETHICS AND DISSEMINATION: WHO Ad Hoc COVID-19 Research Ethics Review Committee (ERC) has approved this global protocol. When this protocol is adopted at specific country sites, national ERCs may make require adjustments in accordance with their respective national research ethics guidelines. Dissemination of this protocol and global findings will be open access through peer-reviewed scientific journals, study website, press and online media. TRIAL REGISTRATION NUMBER: NCT04918875.

Indexed as

COVID-19OxygenChildDeveloping CountriesHumansObservational Studies as TopicPandemicsProspective StudiesSARS-CoV-2World Health OrganizationOxygenACCIDENT & EMERGENCY MEDICINECOVID-19Health policyINTENSIVE & CRITICAL CAREProtocols & guidelinesRESPIRATORY MEDICINE (see Thoracic Medicine)

Identifiers

PMID37591648
PMCPMC10441039

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.