ArticleCurrent biology : CB2023
Anatomical restructuring of a lateralized neural circuit during associative learning by asymmetric insulin signaling.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- A symmetric systemic challenge elicits a right-biased response mediated by vasopressin signaling.Journal of neuroendocrinology · 2026Article
- Inefficacy of a novel osmotic associative learning assay in C. elegans.BMC research notes · 2026Article
- A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
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- Whole-mount diffracted X-ray blinking analysis of intracellular amyloid-β-associated nanoscale dynamics inBiology methods & protocols · 2026Article
- Review
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- Review
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Article
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6 authors at 1 institution in 1 country.
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Abstract
Studies of neuronal connectivity in model organisms, i.e., of their connectomes, have been instrumental in dissecting the structure-function relationship of nervous systems. However, the limited sample size of these studies has impeded analyses into how variation of connectivity across populations may influence circuit architecture and behavior. Moreover, little is known about how experiences induce changes in circuit architecture. Here, we show that an asymmetric salt-sensing circuit in the nematode Caenorhabditis elegans exhibits variation that predicts the animals' salt preferences and undergoes restructuring during salt associative learning. Naive worms memorize and prefer the salt concentration they experience in the presence of food through a left-biased neural network architecture. However, animals conditioned at elevated salt concentrations change this left-biased network to a right-biased network. This change in circuit architecture occurs through the addition of new synapses in response to asymmetric, paracrine insulin signaling. Therefore, experience-dependent changes in an animal's neural connectome are induced by insulin signaling and are fundamental to learning and behavior.
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