Evidence map›Paper›PMID 37591188›Full record

ArticleBiomaterials2023

Biodegradable piezoelectric skin-wound scaffold.

Ritopa Das, Thinh T Le, Benjamin Schiff, Meysam T Chorsi, Jinyoung Park, Priscilla Lam, Andrew Kemerley, Ajayan Mannoor Supran, Amit Eshed, Ngoc Luu and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Ritopa DasDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Thinh T LeDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Benjamin SchiffDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, 06269, USA.
Meysam T ChorsiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA; Department of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Jinyoung ParkDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Priscilla LamMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health School of Medicine, Farmington, 06030, CT, USA.
Andrew KemerleyMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health School of Medicine, Farmington, 06030, CT, USA.
Ajayan Mannoor SupranMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health School of Medicine, Farmington, 06030, CT, USA.
Amit EshedDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Ngoc LuuDepartment of Biomedical Engineering, New York University, New York, NY, 10012, USA.
Nikhil G MenonDepartment of Biomedical Engineering, University of Connecticut Health Center, Farmington, 06030, CT, USA.
Tannin A SchmidtDepartment of Biomedical Engineering, University of Connecticut Health Center, Farmington, 06030, CT, USA; Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.
Hanzhang WangPathology and Laboratory Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Qian WuPathology and Laboratory Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Mahesh ThirunavukkarasuMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health School of Medicine, Farmington, 06030, CT, USA.
Nilanjana MaulikMolecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health School of Medicine, Farmington, 06030, CT, USA.
Thanh D NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA; Department of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA; Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA. Electronic address: nguyentd@uconn.edu.
UConn Health · USUniversity of Connecticut · USBoston University · USNew York University · US

Funding

Biodegradable and Biocompatible Piezoelectric Nanofiber Mat for Wound DressingR21AR076646 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2020 to 2021
$385k
NIAMS NIH HHS R21 AR076646
6 · The paper itself

Abstract

Electrical stimulation (ES) induces wound healing and skin regeneration. Combining ES with the tissue-engineering approach, which relies on biomaterials to construct a replacement tissue graft, could offer a self-stimulated scaffold to heal skin-wounds without using potentially toxic growth factors and exogenous cells. Unfortunately, current ES technologies are either ineffective (external stimulations) or unsafe (implanted electrical devices using toxic batteries). Hence, we propose a novel wound-healing strategy that integrates ES with tissue engineering techniques by utilizing a biodegradable self-charged piezoelectric PLLA (Poly (l-lactic acid)) nanofiber matrix. This unique, safe, and stable piezoelectric scaffold can be activated by an external ultrasound (US) to produce well-controlled surface-charges with different polarities, thus serving multiple functions to suppress bacterial growth (negative surface charge) and promote skin regeneration (positive surface charge) at the same time. We demonstrate that the scaffold activated by low intensity/low frequency US can facilitate the proliferation of fibroblast/epithelial cells, enhance expression of genes (collagen I, III, and fibronectin) typical for the wound healing process, and suppress the growth of S. aureus and P. aeruginosa bacteria in vitro simultaneously. This approach induces rapid skin regeneration in a critical-sized skin wound mouse model in vivo. The piezoelectric PLLA skin scaffold thus assumes the role of a multi-tasking, biodegradable, battery-free electrical stimulator which is important for skin-wound healing and bacterial infection prevention simultaneuosly.

Indexed as

SkinStaphylococcus aureusAnimalsBiocompatible MaterialsCollagen Type IMiceWound HealingBiocompatible MaterialsCollagen Type IBiodegradable piezoelectric nanofibersElectrical stimulationSkin regenerationUltrasoundWound healing

Identifiers

PMID37591188
PMCPMC10528909
OpenAlexW4385667695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.