ArticleDrug and alcohol dependence2023
The relationship between alcohol- and sleep-related traits: Results from polygenic risk score and Mendelian randomization analyses.
Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Trial
- Article
- Network characteristics of comorbid symptoms in alcohol use disorder.Annals of medicine · 2025Article
- Exploration of Genetic Liability to Insomnia and Substance Use Disorders in Patients With Bipolar Disorder.Bipolar disorders · 2025Article
- Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
STUDY
objectivesWe investigated whether genetic risk for insomnia and sleep duration abnormalities are associated with AUD and alcohol consumption. We also evaluated the causal relationships between sleep- and alcohol-related traits.
methodsIndividual-level phenotype and genotype data from the Million Veteran Program were used. Polygenic risk scores (PRS) were computed using summary statistics from two recent discovery GWAS of insomnia (N= 453,379 European-ancestry (EA) individuals) and sleep duration (N= 446,118 EAs) and tested for association with lifetime AUD diagnosis (N= 34,658 EA cases) and past-year Alcohol Use Disorders Identification Test-Consumption scale scores (AUDIT-C, N= 200,680 EAs). Bi-directional two-sample Mendelian Randomization (MR) analyses assessed causal associations between the two sleep traits and the two alcohol-related traits.
resultsThe insomnia PRS was positively associated with AUD at 2/9 PRS thresholds, with p<0.01 being the most significant (OR = 1.02, p = 3.48 × 10
conclusionThe genetic risk for insomnia shows pleiotropy with AUD, and sleep continuity abnormalities have a causal influence on the development of AUD.
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Registered trials
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