ArticleSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2023
Assessment of spatially offset Raman spectroscopy to detect differences in bone matrix quality.
Article in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Machine learning reconstruction of digit bone Raman spectra enables noninvasive transcutaneous detection of systemic osteoporosis.Biomedical optics express · 2026Article
- Optical phantoms for the characterization and validation of imaging and spectroscopy: a review.Biophotonics discovery · 2026Review
- In vivo Raman spectroscopy for real-time biochemical assessment of tissue pathology and physiology.Nature protocols · 2026Review
- Predicting wrist osteoporosis from excised human finger bones using spatially offset Raman spectroscopy - a cadaveric study.Biomedical optics express · 2026Article
- Raman spectroscopic fingerprinting uncovers a multi-scale structural-mechanical-transcriptomic coupling landscape in osteoporosis.Frontiers in endocrinology · 2026Article
- Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging.Journal of biomedical optics · 2025Article
- Article
- Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms.Bone reports · 2025Article
- Broadband time domain diffuse optical characterization of human cadaver bone from 500 to 1100 nm.Scientific reports · 2025Article
- Optimizing number of Raman spectra using an artificial neural network guided Monte Carlo simulation approach to analyze human cortical bone.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2025Article
- Article
- Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation.Nano convergence · 2024Review
- In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024Review
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Abstract
Since spatially offset Raman spectroscopy (SORS) can acquire biochemical measurements of tissue quality through light scattering materials, we investigated the feasibility of this technique to acquire Raman bands related to the fracture resistance of bone. Designed to maximize signals at different offsets, a SORS probe was used to acquire spectra from cadaveric bone with and without skin-like tissue phantoms attenuating the light. Autoclaving the lateral side of femur mid-shafts from 5 female and 5 male donors at 100 °C and again at 120 °C reduced the yield stress of cortical beams subjected to three-point bending. It did not affect the volumetric bone mineral density or porosity. Without tissue phantoms, autoclaving affected more Raman characteristics of the organic matrix when determined by peak intensity ratios, but fewer matrix properties depended on the three offsets (5 mm, 6 mm, and 7 mm) when determined by band area ratios. The cut-off in the thickness of the tissue phantom layers was ∼4 mm for most properties, irrespective of offset. Matching trends when spectra were acquired without phantom layers between bone and the probe, ν
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