Evidence map›Paper›PMID 37590414›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons.

Veronika Kondev, Mustafa Najeed, Niharika Loomba, Jordan Brown, Danny G Winder, Brad A Grueter, Sachin Patel

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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  9. CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Veronika KondevVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232.
Mustafa NajeedVanderbilt University, Nashville, TN 37232.ORCID 0000-0001-5160-2990
Niharika LoombaVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232.
Jordan BrownDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232.ORCID 0000-0002-0256-8412
Danny G WinderDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Brad A GrueterVanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN 27323.ORCID 0000-0002-4224-3866
Sachin PatelNorthwestern Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0001-8052-520X
Vanderbilt University · USNorthwestern University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptationR01MH107435 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, SACHIN · 2016 to 2025
$5.0M
Parvalbumin interneurons regulate nucleus accumbens synapses and behaviorR01DA040630 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRUETER, BRAD ALAN · 2016 to 2025
$4.5M
Endocannabinoid regulation of ventral hippocampus-nucleus accumbens circuit and consequences for stress-mediated behaviorsF31MH126460 · NIMH · VANDERBILT UNIVERSITY · PI KONDEV, VERONIKA · 2022 to 2023
$43k
NICHD NIH HHS P50 HD103537NIDA NIH HHS R01 DA040630NIMH NIH HHS F31 MH126460NIMH NIH HHS R01 MH107435
6 · The paper itself

Abstract

Interneuron populations within the nucleus accumbens (NAc) orchestrate excitatory-inhibitory balance, undergo experience-dependent plasticity, and gate-motivated behavior, all biobehavioral processes heavily modulated by endogenous cannabinoid (eCB) signaling. While eCBs are well known to regulate synaptic plasticity onto NAc medium spiny neurons and modulate NAc function at the behavioral level, how eCBs regulate NAc interneuron function is less well understood. Here, we show that eCB signaling differentially regulates glutamatergic and feedforward GABAergic transmission onto NAc somatostatin-expressing interneurons (NAc

Indexed as

CannabinoidsEndocannabinoidsNeuronsNucleus AccumbensSomatostatinCannabinoidsEndocannabinoidsSomatostatincannabinoidcannabisglutamateplasticitystress

Identifiers

PMID37590414
PMCPMC10450650
OpenAlexW4385928740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.