Evidence map›Paper›PMID 37590372›Full record

ArticleScience (New York, N.Y.)2023

DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in

Yisui Xia, Remi Sonneville, Michael Jenkyn-Bedford, Liqin Ji, Constance Alabert, Ye Hong, Joseph T P Yeeles, Karim P M Labib

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer.Apoptosis : an international journal on programmed cell death · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Structure of the Saccharolobus solfataricus GINS tetramer.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yisui Xia *The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0000-0002-5576-2147
Remi Sonneville *The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Michael Jenkyn-Bedford *MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.ORCID 0000-0003-2335-8278
Liqin JiShandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.
Constance AlabertDivision of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.
Ye HongThe MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0009-0005-7980-6414
Joseph T P YeelesMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.ORCID 0000-0002-2255-2119
Karim P M LabibThe MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID 0000-0001-8861-379X
University of Dundee · GBMRC Laboratory of Molecular Biology · GBShandong University · CN

Funding

Cancer Research UK 21782Cancer Research UK 24558Cancer Research UK DRCRPG-NOV22/100016Medical Research Council MC_UP_1201/12Medical Research Council MC_UU_00018/4Medical Research Council MC_UU_12016/13
6 · The paper itself

Abstract

Assembly of the CMG (CDC-45-MCM-2-7-GINS) helicase is the key regulated step during eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require additional factors that are not present in yeast. In this work, we show that

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDNA ReplicationMinichromosome Maintenance ProteinsAnimalsCell Cycle ProteinsChromosomal Proteins, Non-HistoneCryoelectron MicroscopyProtein DomainsCaenorhabditis elegans ProteinsCell Cycle ProteinsChromosomal Proteins, Non-Histoneevl-18 protein, C elegansMinichromosome Maintenance Proteins

Identifiers

PMID37590372
PMCPMC7615117
OpenAlexW4385931519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.