Evidence map›Paper›PMID 37590033›Full record

ArticleAdvanced healthcare materials2023

Anti-HER2 Super Stealth Immunoliposomes for Targeted-Chemotherapy.

Elena Canato, Antonella Grigoletto, Ilaria Zanotto, Tommaso Tedeschini, Benedetta Campara, Giovanna Quaglio, Giuseppe Toffoli, Delia Mandracchia, Alberto Dinarello, Natascia Tiso and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Elena CanatoDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Antonella GrigolettoDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Ilaria ZanottoDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Tommaso TedeschiniDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Benedetta CamparaDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Giovanna QuaglioDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Giuseppe ToffoliExperimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini n. 2, Aviano, 33081, Italy.
Delia MandracchiaDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, 25123, Italy.
Alberto DinarelloDepartment of Biology, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.
Natascia TisoDepartment of Biology, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.
Francesco ArgentonDepartment of Biology, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.
Katia SayafDepartment Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 2, Padova, 35131, Italy.
Maria GuidoDepartment of Medicine-DIMED, University of Padova, Padua, 35128, Italy.
Daniela GabbiaDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Sara De MartinDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.
Gianfranco PasutDepartment Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, Padova, 35131, Italy.ORCID 0000-0002-8754-0899
University of Padua · ITCentro di Riferimento Oncologico · ITUniversity of Brescia · IT

Funding

AIRC IG-2017-19928AIRC IG-2017-20244Cariparo Foundation 55828Telethon Foundation GGP19287
6 · The paper itself

Abstract

Liposomes play an important role in the field of drug delivery by virtue of their biocompatibility and versatility as carriers. Stealth liposomes, obtained by surface decoration with hydrophilic polyethylene glycol (PEG) molecules, represent an important turning point in liposome technology, leading to significant improvements in the pharmacokinetic profile compared to naked liposomes. Nevertheless, the generation of effective targeted liposomes-a central issue for cancer therapy-has faced several difficulties and clinical phase failures. Active targeting remains a challenge for liposomes. In this direction, a new Super Stealth Immunoliposomes (SSIL2) composed of a PEG-bi-phospholipids derivative is designed that stabilizes the polymer shielding over the liposomes. Furthermore, its counterpart, conjugated to the fragment antigen-binding of trastuzumab (Fab'

Indexed as

LiposomesNeoplasmsAnimalsDrug Delivery SystemsPhospholipidsPolyethylene GlycolsZebrafishLiposomesPhospholipidsPolyethylene Glycolsanticancer therapydoxorubicindrug targetingliposomestargeted chemotherapytrastuzumab

Identifiers

PMID37590033
PMCPMC11469322
OpenAlexW4385897868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.