Evidence map›Paper›PMID 37589806›Full record

ArticleAIDS and behavior2024

Identifying Adolescents at Highest Risk of ART Non-adherence, Using the World Health Organization-Endorsed HEADSS and HEADSS+ Checklists.

Lucie D Cluver, Yulia Shenderovich, Marko Seslija, Siyanai Zhou, Elona Toska, Alice Armstrong, Laurie A Gulaid, Wole Ameyan, Matteo Cassolato, Caroline C Kuo and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Lucie D Cluver *Centre for Evidence-Based Intervention, Department of Social Policy & Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford, OX1 2ER, UK. lucie.cluver@spi.ox.ac.uk.ORCID http://orcid.org/0000-0002-0418-835X
Yulia Shenderovich *Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, UK.
Marko Seslija *Centre for Evidence-Based Intervention, Department of Social Policy & Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford, OX1 2ER, UK.
Siyanai ZhouCentre for Social Science Research, University of Cape Town, Cape Town, South Africa.
Elona ToskaCentre for Evidence-Based Intervention, Department of Social Policy & Intervention, University of Oxford, Barnett House, 32 Wellington Square, Oxford, OX1 2ER, UK.
Alice ArmstrongUNICEF Eastern and Southern Africa Regional Office, Nairobi, Kenya.
Laurie A GulaidUNICEF Eastern and Southern Africa Regional Office, Nairobi, Kenya.
Wole AmeyanGlobal HIV, Hepatitis and Sexually Transmitted Infections Programmes, World Health Organization, Geneva, Switzerland.
Matteo CassolatoFrontline AIDS, Brighton, UK.
Caroline C KuoDepartment of Health Studies, American University, Washington, DC, USA.
Christina LaurenziDepartment of Global Health, Institute for Life Course Health Research, Stellenbosch University, Stellenbosch, South Africa.
Lorraine SherrHealth Psychology Unit, Institute of Global Health, University College London, London, UK.
University of Cape Town · ZAAmerican University · USCardiff University · GBOxford Policy Management · GBStellenbosch University · ZAUniversity College London · GBWorld Health Organization · CH

Funding

Undetectable and Untransmittable: reducing HIV transmission among young women living with HIV, their partners and children in South AfricaK43TW011434 · FIC · UNIVERSITY OF CAPE TOWN · PI TOSKA, ELONA · 2019 to 2023
$720k
FIC NIH HHS K43 TW011434Medical Research Council MR/R022372/1NIH HHS K43TW011434World Health Organization 001
6 · The paper itself

Abstract

Brief tools are necessary to identify adolescents at greatest risk for ART non-adherence. From the WHO's HEADSS/HEADSS+ adolescent wellbeing checklists, we identify constructs strongly associated with non-adherence (validated with viral load). We conducted interviews and collected clinical records from a 3-year cohort of 1046 adolescents living with HIV from 52 South African government facilities. We used least absolute shrinkage and selection operator variable selection approach with a generalized linear mixed model. HEADSS constructs most predictive were: violence exposure (aOR 1.97, CI 1.61; 2.42, p < 0.001), depression (aOR 1.71, CI 1.42; 2.07, p < 0.001) and being sexually active (aOR 1.80, CI 1.41; 2.28, p < 0.001). Risk of non-adherence rose from 20.4% with none, to 55.6% with all three. HEADSS+ constructs were: medication side effects (aOR 2.27, CI 1.82; 2.81, p < 0.001), low social support (aOR 1.97, CI 1.60; 2.43, p < 0.001) and non-disclosure to parents (aOR 2.53, CI 1.91; 3.53, p < 0.001). Risk of non-adherence rose from 21.6% with none, to 71.8% with all three. Screening within established checklists can improve identification of adolescents needing increased support. Adolescent HIV services need to include side-effect management, violence prevention, mental health and sexual and reproductive health.

Indexed as

HIV InfectionsAdolescentChecklistHumansMedication AdherenceMental HealthSocial SupportAdolescentsAIDSHealth personnelHIVMental healthTreatment

Identifiers

PMID37589806
PMCPMC10803572
OpenAlexW4385897702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.