Evidence map›Paper›PMID 37589717›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Enzymatic Benzofuranoindoline Formation in the Biosynthesis of the Strained Bridgehead Bicyclic Dipeptide (+)-Azonazine A.

Mengting Liu, Masao Ohashi, Qingyang Zhou, Jacob N Sanders, Erin P McCauley, Phillip Crews, K N Houk, Yi Tang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mengting LiuDepartment of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry University of California, Los Angeles, California, 90095, USA.ORCID 0000-0001-9167-733X
Masao OhashiDepartment of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry University of California, Los Angeles, California, 90095, USA.ORCID 0000-0001-7103-541X
Qingyang ZhouDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, 90095, USA.
Jacob N SandersDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, 90095, USA.
Erin P McCauleyDepartment of Chemistry and Biochemistry, California State University-Dominguez Hills, Carson, California, 90747, USA.
Phillip CrewsDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, California, 95064, USA.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California, 90095, USA.ORCID 0000-0002-8387-5261
Yi TangDepartment of Chemical and Biomolecular Engineering, Department of Chemistry and Biochemistry University of California, Los Angeles, California, 90095, USA.ORCID 0000-0003-1597-0141
University of California, Los Angeles · USCalifornia State University, Dominguez Hills · USUniversity of California, Santa Cruz · US

Funding

MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1M
NIGMS NIH HHS R35 GM118056NIGMS NIH HHS R35GM118056
6 · The paper itself

Abstract

We uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)-azonazine A from marine-derived Aspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo-(l-Trp-N-methyl-l-Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole-substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs.

Indexed as

Cytochrome P-450 Enzyme SystemDipeptidesCyclizationOxidation-ReductionazonazineCytochrome P-450 Enzyme SystemDipeptidesBenzofuranoindolinesBiosynthesisIndole AlkaloidsOxidative Cyclization

Identifiers

PMID37589717
PMCPMC10868402
OpenAlexW4385898668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.