Evidence map›Paper›PMID 37589596›Full record

Trial reportJournal of the Pediatric Infectious Diseases Society2023

Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso.

Alphonse Ouedraogo, Amidou Diarra, Issa Nébié, Nouhoun Barry, Jean Moise Kabore, Alfred B Tiono, Shrimati Datta, Yuanyuan Liang, Ifayet Mayo, Jennifer J Oshinsky and 7 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled TrialClinical Trial, Phase II
In one paragraph

Trial report in Journal of the Pediatric Infectious Diseases Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07624175 (Immunogenicity and Tolerability of Typhoid Conjugate Vaccine), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07624175 phase2completednot on this mapstarted 2024, after this paper: background citation

Immunogenicity and Tolerability of Typhoid Conjugate Vaccine (TCV) 5-6 Years After Routine Vaccines Administered With or Without TCV Among Children Younger Than 2 Years in Ouagadougou, Burkina Faso

TypeinterventionalSponsorKathleen NeuzilRan2024 to 2024Enrolled147ConditionsTyphoidArmsVi capsular polysaccharide-CRM197 conjugate vaccine (Vi-CRM), 0.5 mL IM
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Longevity of immune response after a single dose of typhoid conjugate vaccine against Salmonella Typhi among children in Hyderabad, Pakistan.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  4. Genotypic Diversity amongInternational journal of clinical microbiology · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Alphonse OuedraogoGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Amidou DiarraGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Issa NébiéGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Nouhoun BarryGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Jean Moise KaboreGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Alfred B TionoGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Shrimati DattaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yuanyuan LiangCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ifayet MayoCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jennifer J OshinskyCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Kathleen TracyCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Tsion GirmayCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Marcela F PasettiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Leslie P JamkaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4997-4570
Kathleen M NeuzilCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sodiomon B SirimaGroupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Matthew B LaurensCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3874-581X
University of Maryland, Baltimore · USGroupe de Recherche et d’Action sur le Foncier · BF

Funding

Bill and Melinda Gates Foundation OPP1151153
6 · The paper itself

Abstract

We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15 months.

Indexed as

Typhoid FeverTyphoid-Paratyphoid VaccinesAntibodies, BacterialAntibody FormationBurkina FasoChildHumansImmunoglobulin AImmunoglobulin GInfantVaccines, ConjugateAntibodies, BacterialImmunoglobulin AImmunoglobulin GTyphoid-Paratyphoid VaccinesVaccines, ConjugateAfricaBurkina FasoIgA and IgGimmunogenicitytyphoid conjugate vaccine

Identifiers

PMID37589596
PMCPMC10533206
OpenAlexW4385898227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.