Evidence map›Paper›PMID 37589159›Full record

ReviewJournal of the American Heart Association2023

Diagnostic Approach for Suspected Acute Myocarditis: Considerations for Standardization and Broadening Clinical Spectrum.

Pieter Martens, Leslie T Cooper, W H Wilson Tang

Open access · goldAbstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Incidence and predictors of major arrhythmic events after myocarditis: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
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  7. Myopericarditis in an emergency department patient presenting with chest pain and ECG changes: a case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
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  9. Quantitative evaluation ofAnnals of nuclear medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pieter MartensDepartment of Cardiovascular Medicine Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-6036-2113
Leslie T CooperDepartment of Cardiovascular Medicine Mayo Clinic Jacksonville FL USA.ORCID 0000-0003-1002-3313
W H Wilson TangDepartment of Cardiovascular Medicine Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-8335-735X
Cleveland Clinic · USJacksonville College · US

Funding

International Consortium for Multimodality Phenotyping in Adults with Non-compactionR01HL146754 · NHLBI · STANFORD UNIVERSITY · PI NIEMAN, KOEN, TANG, WAI HONG WILSON · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL146754
6 · The paper itself

Abstract

Myocarditis is most recognized in patients with moderate to severe, recent-onset heart failure. However, less typical presentations including myocardial infarction with normal coronary arteries and arrhythmias are important manifestations but less commonly recognized to be caused by myocarditis. Most cases of myocarditis can be self-limiting without specific treatment; however, appropriate identification of risk during the diagnostic process of myocarditis and once a diagnosis is established is of primordial importance to identify patients in need for more specific follow-up and management. We propose a flexible, multitiered approach to the diagnostic process, allowing for capturing of the spectrum of myocarditis at an early time-point, individualized use of diagnostic resources through disease severity phenotyping, and providing structured follow-up care once myocarditis is confirmed. Such diagnostic processes allow for identification of specific etiologies with potential therapeutic consequences or allows for the comprehension of disease chronicity by understanding genetic contributions or elements of persistent immune dysregulation and degree of cardiac damage. The article highlights the evolving field of immunophenotyping in myocarditis, generating a potential for the development of targeted therapeutic approaches. Currently long-term follow-up should be titrated to the refined risk assessments of patients with a diagnosis of myocarditis and includes arrhythmia monitoring and imaging when the results will likely impact management. Genetic testing should be considered in selected cases, and histologic diagnosis may be considered in nonresponders even at later stages.

Indexed as

MyocarditisGenetic TestingHeartHumansImmunophenotypingReference Standardscardioimmunologycare pathwaygeneticsmanagementmyocarditis

Identifiers

PMID37589159
PMCPMC10547314
OpenAlexW4385897351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.