ArticleJSES reviews, reports, and techniques2021
Fatty degeneration of the rotator cuff: pathogenesis, clinical implications, and future treatment.
Article in JSES reviews, reports, and techniques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Clinical and functional outcomes of subacromial spacer implantation and superior capsular reconstruction for massive irreparable rotator cuff tears: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Reliability of imaging assessment of fatty infiltration in rotator cuff disorders: protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Validation of Three-Dimensional Magnetic Resonance Imaging-Based Volumetric Quantification for Fatty Infiltration in a Rabbit Model of Chronic Rotator Cuff Tears.Diagnostics (Basel, Switzerland) · 2026Article
- Tendon-muscle-nerve disconnection in chronic large and massive posterosuperior rotator cuff tears: a targeted narrative mechanistic review and hypothesis-generating framework.Frontiers in cell and developmental biology · 2026Review
- Oxandrolone treatment prevents muscle atrophy and retraction after rotator cuff injury: an experimental study in rats.JSES reviews, reports, and techniques · 2025Article
- Preoperative serum vitamin D deficiency is associated with increased rotator cuff fatty degeneration but is unlikely to influence post repair outcomes: a systematic review and meta-analysis of correlation coefficients.JSES reviews, reports, and techniques · 2025Review
- NEDD4 enhances bone‑tendon healing in rotator cuff tears by reducing fatty infiltration.Molecular medicine reports · 2025Article
- Influence of statin use on progression of postoperative fatty infiltration in the arthroscopic rotator cuff repair.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Compositional and Functional MRI of Skeletal Muscle: A Review.Journal of magnetic resonance imaging : JMRI · 2024Review
- A deep learning approach for fast muscle water T2 mapping with subject specific fat T2 calibration from multi-spin-echo acquisitions.Scientific reports · 2024Article
- Rotator Cuff Injury: Pathogenesis, Biomechanics, and Repair.Journal of orthopaedics and sports medicine · 2024Article
- Predictors of infraspinatus muscle degeneration in individuals with an isolated supraspinatus tendon tear.Skeletal radiology · 2023Article
- Distinct human skeletal muscle-derived CD90 progenitor subsets for myo-fibro-adipogenic disease modeling and treatment in multiplexed conditions.Frontiers in cell and developmental biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic rotator cuff pathology is often complicated by fatty degeneration of the rotator cuff (FDRC) muscles, an insidious process associated with poor prognosis with or without surgical intervention. Currently there is no treatment for FDRC, and many studies have described a natural course for this disease almost always resulting in further degeneration and morbidity. Recapitulating FDRC using animal injury models, and using imaging-based studies of human FDRC, the pathophysiology of this disease continues to be further characterized. Researchers studying mesenchymal stem cell-derived progenitor cells and known fibrogenic and adipogenic signaling pathways implicated in FDRC seek to clarify the underlying processes driving these changes. While new cell- and molecular-based therapies are being developed, currently the strongest available avenue for improved management of FDRC is the use of novel imaging techniques which allow for more accurate and personalized staging of fatty degeneration. This narrative review summarizes the evidence on the molecular and pathophysiologic mechanisms of FDRC and provides a clinical update on the diagnosis and management of this condition based on the existing knowledge. We also sought to examine the role of newer biologic therapies in the management of RC fatty degeneration and to identify areas of future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.