Evidence map›Paper›PMID 37588271›Full record

ArticleBJA open2022

Impact of perioperative inflammation on days alive and at home after surgery.

David Kunkel, Margaret Parker, Cameron Casey, Bryan Krause, Jennifer Taylor, Robert A Pearce, Richard Lennertz, Robert D Sanders

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJA open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03124303 (Interventions for Postoperative Delirium), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03124303 recruitingnot on this map

Interventions for Postoperative Delirium: Biomarker-3

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2017 to 2029Enrolled468ConditionsDeliriumArmsHigh Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection, Pupillometry
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

David KunkelDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Margaret ParkerDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Cameron CaseyDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Bryan KrauseDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Jennifer TaylorFaculty of Medicine and Health, University of Sydney, Sydney, Australia.
Robert A PearceDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Richard LennertzDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Robert D SandersFaculty of Medicine and Health, University of Sydney, Sydney, Australia.
University of Wisconsin–Madison · USRoyal Prince Alfred Hospital · AUUniversity of Sydney · AU

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
NIA NIH HHS R01 AG063849
6 · The paper itself

Abstract

Background: Perioperative inflammation is associated with perioperative complications, including delirium, that are associated with a reduced number of postoperative days alive and at home at 90 days (DAH90). We tested whether inflammation was associated with DAH90 even when adjusting for perioperative factors, and whether inflammation independently was associated with DAH90 when adjusting for delirium. Methods: We conducted a prospective cohort study of major, non-intracranial surgical patients who were older than 65 yr ( Results: Before adjusting for delirium, a postoperative day 1 increased IL-8 was associated with fewer DAH90 at the 0.75 quantile (β=-0.082; 95% confidence interval [CI], -0.19 to -0.006) after adjusting for demographic (age and sex) and perioperative factors (cardiovascular surgery, National Surgical Quality Improvement Program risk of death, and operative time). IL-10 was similarly associated with DAH90 at the 0.5 (β=-0.026; 95% CI, -0.19 to -0.001) and 0.75 (β= -0.035; 95% CI, -0.07 to -0.006) quantiles. Neither cytokine was significantly associated with DAH90 once delirium and baseline Trail Making Test B were added to the models. Conclusions: Perioperative inflammation predicts DAH90, but when delirium is added to the model inflammation loses significance as a predictor, whereas delirium is significant. Targeting perioperative inflammation may reduce delirium and moderate hospital readmission and mortality. Clinical trial registration: NCT03124303.

Indexed as

days alive and at homedeliriumhospital readmissioninflammationmortalitysurgery

Identifiers

PMID37588271
PMCPMC10430844
OpenAlexW4223919507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.