Evidence map›Paper›PMID 37588188›Full record

ArticleGenes & diseases2024

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia.

Dongsheng Zhang, Wenjuan Tang, Haitao Niu, William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang and 6 more

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Genes & diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. CDC42 Regulatory Patterns Related To Inflammatory Bowel Disease and Hyperglycemia.Journal of bioinformatics and systems biology : Open access · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 4 countries.

Dongsheng ZhangDivision of Hematology and Oncology, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 44109, USA.
Wenjuan TangDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Haitao NiuSchool of Medicine, Jinan University, Guangzhou, Guangdong 510632, China.
William TseDivision of Hematology and Oncology, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 44109, USA.
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MI 55455, USA.
Helmut DolznigInstitute of Medical Genetics, Medical University of Vienna, Vienna 1040, Austria.
Thomas KnöselInstitute of Pathology, Ludwig-Maximilians-University Munich, Munich 80539, Germany.
Friedrich Karl-HeinzInstitute of Biochemistry II, University Hospital Jena, Jena 07743, Germany.
Madeleine ThemannsLaboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
Jiang WangDepartment of Pathology, University of Cincinnati, Cincinnati, OH 45221, USA.
Mingquan SongDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266005, China.
Lee DensonDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Lukas KennerDepartment of Pathology, Medical University of Vienna, Vienna 1040, Austria.
Richard MorigglLudwig Boltzmann Institute for Cancer Research, Vienna 1090, Austria.
Yi ZhengDivision of Experimental Hematology, CCHMC, Cincinnati, OH 45229, USA.
Xiaonan HanDivision of Hematology and Oncology, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 44109, USA.
Cincinnati Children's Hospital Medical Center · USMedical University of Vienna · ATMetroHealth Medical Center · USUniversity of Veterinary Medicine Vienna · ATJena University Hospital · DEJinan University · CNLudwig-Maximilians-Universität München · DEQingdao University · CNUniversity of Cincinnati · USUniversity of Minnesota Medical Center · US

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
REGULATION OF NICHE CELL DIFFERENTIATION TO SUSTAIN INTESTINAL STEM CELL REGENERATION AGAINST GUT INFLAMMATIONR01DK123299 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HAN, XIAONAN · 2020 to 2023
$1.4M
NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK123299
6 · The paper itself

Abstract

CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to determine the loss of intestinal

Indexed as

Cell division cycle 42 (CDC42)ColitisColorectal cancer (CRC)Inflammatory bowel diseases (IBD)Intestinal epithelial cell (IEC)Intestinal epithelial stem cell (IESC)Irradiation

Identifiers

PMID37588188
PMCPMC10425749
OpenAlexW4313427286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.