Evidence map›Paper›PMID 37588093›Full record

ReviewFrontiers in oncology2023

Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer.

Emily A Henderson, Slawomir Lukomski, Brian A Boone

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Emily A HendersonDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United States.
Slawomir LukomskiDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United States.
Brian A BooneDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United States.
Virginia Cancer Institute · USWest Virginia University · US

Funding

WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4M
Mechanisms of anti-tumor activity of group A Streptococcus in pancreatic adenocarcinomaR21CA267302 · NCI · WEST VIRGINIA UNIVERSITY · PI BOONE, BRIAN A, LUKOMSKI, SLAWOMIR · 2022 to 2023
$387k
NCI NIH HHS R21 CA267302NIGMS NIH HHS P20 GM121322
6 · The paper itself

Abstract

Pancreatic cancer is a highly aggressive form of cancer with a five-year survival rate of only ten percent. Pancreatic ductal adenocarcinoma (PDAC) accounts for ninety percent of those cases. PDAC is associated with a dense stroma that confers resistance to current treatment modalities. Increasing resistance to cancer treatments poses a challenge and a need for alternative therapies. Bacterial mediated cancer therapies were proposed in the late 1800s by Dr. William Coley when he injected osteosarcoma patients with live streptococci or a fabrication of heat-killed

Indexed as

anti-tumor immunitybacterial therapybioengineeringimmunotherapypancreatic ductal adenocarcinoma

Identifiers

PMID37588093
PMCPMC10425600
OpenAlexW4385411881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.