Evidence map›Paper›PMID 37588007›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2023

Tacrolimus Exposure Before and After a Switch From Twice-Daily Immediate-Release to Once-Daily Prolonged Release Tacrolimus: The ENVARSWITCH Study.

Caroline Monchaud, Jean-Baptiste Woillard, Sabrina Crépin, Naïma Tafzi, Ludovic Micallef, Jean-Philippe Rerolle, Sébastien Dharancy, Filomena Conti, Gabriel Choukroun, Antoine Thierry and 12 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02882828 (Pharmacokinetic Assessment of Tacrolimus Exposure Before and After a Switch From Twice Daily Immediate-release), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02882828 phase4completednot on this map

Pharmacokinetic Assessment of Tacrolimus Exposure Before and After a Switch From Twice Daily Immediate-release (Prograf®) to Once-daily Prolonged Release Tacrolimus (Envarsus®)

TypeinterventionalSponsorUniversity Hospital, LimogesRan2016 to 2020Enrolled134ConditionsAllograftArmsswitched from Prograf® to Envarsus®
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 16 institutions in 1 country.

Caroline MonchaudDepartment of Pharmacology, Toxicology and Pharmacovigilance, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Jean-Baptiste WoillardDepartment of Pharmacology, Toxicology and Pharmacovigilance, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Sabrina CrépinDepartment of Pharmacology, Toxicology and Pharmacovigilance, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Naïma TafziDepartment of Pharmacology, Toxicology and Pharmacovigilance, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Ludovic MicallefDepartment of Pharmacology, Toxicology and Pharmacovigilance, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Jean-Philippe RerolleINSERM1248 Pharmacolgy and Transplantation, Limoges, France.
Sébastien DharancyDepartment of Hepatology-Transplantation, CHU Lille, Lille, France.
Filomena ContiDepartment of Hepato-Gastro-Enterology, Hôpital Pitié-Salpêtrière, Paris, France.
Gabriel ChoukrounDepartment of Nephrology, Internal Medicine, Transplantation, Centre Hospitalier Universitaire (CHU) d'Amiens, Amiens, France.
Antoine ThierryFédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Poitiers, France.
Matthias BuchlerFédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Tours, France.
Ephrem SalaméFédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Tours, France.
Cyril GarrousteDepartment of Nephrology-Hemodialyses, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
Christophe DuvouxDepartment of Hepatology, Hôpital Henri-Mondor, Assistance Publique Hôpitaux de Paris, Créteil, France.
Charlotte ColosioDepartment of Nephrology, Centre Hospitalier Universitaire de Reims, Reims, France.
Pierre MervilleDepartment of Nephrology, Transplantation, Dialysis and Aphereses, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Dany AnglicheauDepartment of Kidney and Metabolism Diseases, Transplantation and Clinical Immunology, Hôpital Necker-Enfants Malades, Paris, France.
Isabelle EtienneDepartment of Nephrology, Hemodialysis, Transplantation, Centre Hospitalier Universitaire (CHU) de Rouen, Rouen, France.
Faouzi SalibaHôpital Paul Brousse, Villejuif, France.
Christophe MariatDepartment of Nephrology, Dialysis and Renal Transplantation, Centre Hospitalier Universitaire (CHU) de Saint-Étienne, Saint-Etienne, France.
Marilyne Debette-GratienINSERM1248 Pharmacolgy and Transplantation, Limoges, France.
Pierre MarquetDepartment of Pharmacology, Toxicology and Pharmacovigilance, Centre Hospitalier Universitaire de Limoges, Limoges, France.
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine · FRCentre Hospitalier Universitaire de Limoges · FRInstitut de Transplantation Urologie en Nephrologie · FRUniversité de Limoges · FRCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRCentre Hospitalier Universitaire de Reims · FRCentre Hospitalier Universitaire de Rouen · FRCentre Hospitalier Universitaire de Saint-Étienne · FRCentre Hospitalier Universitaire de Tours · FRHôpital Necker-Enfants Malades · FRHôpital Paul-Brousse · FRHôpitaux Universitaires Henri-Mondor · FRInserm · FRMetabolism and Renal Physiology · FRPitié-Salpêtrière Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LCP-tacrolimus displays enhanced oral bioavailability compared to immediate-release (IR-) tacrolimus. The ENVARSWITCH study aimed to compare tacrolimus AUC

Indexed as

KidneyTacrolimusBayes TheoremHumansTacrolimusAUC monitoringconversiondose individualizationdried blood spotskidney transplantationLCP-tacrolimusliver transplantationtherapeutic drug monitoring

Identifiers

PMID37588007
PMCPMC10425592
OpenAlexW4385460726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.