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ArticleJMIR research protocols2023

Comparing the Efficacy of an Electronically Delivered Cognitive Behavioral Therapy Program to a Mental Health Check-In Program for Generalized Anxiety Disorder: Protocol for a Randomized Trial.

Callum Stephenson, Anchan Kumar, Niloufar Malakouti, Niloofar Nikjoo, Jasleen Jagayat, Tessa Gizzarelli, Charmy Patel, Gilmar Gutierrez, Amirhossein Shirazi, Megan Yang and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in JMIR research protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04754438 (Comparing the Efficacy of an Electronically Delivered Cognitive Behavioural Therapy Program to a Mental Health Coaching Program for Generalized Anxiety Disorder), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04754438 nacompletednot on this map

Comparing the Efficacy of an Electronically Delivered Cognitive Behavioural Therapy Program to a Mental Health Coaching Program for Generalized Anxiety Disorder

TypeinterventionalSponsorDr. Nazanin AlaviRan2021 to 2023Enrolled96ConditionsAnxiety, Generalized Anxiety DisorderArmse-CBT, Mental Health Coaching
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Callum Stephenson *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0002-7929-1546
Anchan Kumar *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0002-8850-8495
Niloufar Malakouti *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0001-9752-8597
Niloofar Nikjoo *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0002-2137-5878
Jasleen Jagayat *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0002-1709-0773
Tessa Gizzarelli *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0003-2490-4189
Charmy Patel *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0009-0005-2915-303X
Gilmar Gutierrez *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0003-0337-3737
Amirhossein Shirazi *OPTT Inc, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-8586-3707
Megan YangDepartment of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0001-6365-2039
Mohsen Omrani *OPTT Inc, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-0461-1947
Nazanin Alavi *Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0001-8710-6067

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGeneralized anxiety disorder (GAD) is a prevalent anxiety disorder, with cognitive behavioral therapy (CBT) being the gold standard treatment. However, it is inaccessible and costly to many, as the mental health industry is overwhelmed by the demand for treatment. This means effective, accessible, and time-saving strategies must be developed to combat these problems. Web-based interventions for mental health disorders are an innovative and promising way to address these barriers. While electronically delivered CBT (e-CBT) has already proved productive and scalable for treating anxiety, other less resource-intensive interventions can be innovated. Checking up on mental health face-to-face has been shown to provide similar benefits to patients with anxiety disorders previously, but more research is needed to evaluate the efficacy of web-based delivery of this intervention.

objectiveThis study will compare the efficacy of e-CBT and a web-based mental health check-in program to treat GAD. These programs will both be delivered through a secure, web-based care delivery platform.

methodsWe will randomly allocate participants (N=100) who are 18 years or older with a confirmed diagnosis of GAD to either an e-CBT program or a mental health check-in program over 12 weeks to address their anxiety symptoms. Participants in the e-CBT arm will complete predesigned modules and homework assignments while receiving personalized feedback and asynchronous interaction with a therapist through the platform. Participants in the mental health check-in arm will be contacted weekly through the web-based platform's written chat feature (messaging system). Therapists will ask the participants a series of predesigned questions that revolve around a different theme each week to prompt conversation. Using clinically validated questionnaires, the efficacy of the e-CBT arm will be compared to the mental health check-in arm. These questionnaires will be completed at baseline, week 6, and week 12.

resultsThe study received ethics approval in April 2021, and participant recruitment began in May 2021. Participant recruitment has been conducted through targeted advertisements and physician referrals. Complete data collection and analysis are expected to conclude by August 2023. Linear and binomial regression (continuous and categorical outcomes, respectively) will be conducted.

conclusionsTo the research team's knowledge, this will be the first study to date comparing the efficacy of e-CBT with a web-based mental health check-in program to treat GAD. The findings from this study can help progress the development of more scalable, accessible, and efficacious mental health treatments.

trial registrationClinicalTrials.gov NCT04754438; https://classic.clinicaltrials.gov/ct2/show/NCT04754438. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/48899.

Indexed as

anxietycognitive behavioral therapyeHealthelectronic caregeneralized anxiety disorderinternetmental healthpsychotherapytreatmentweb-based

Identifiers

PMID37587552
PMCPMC10551799

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.